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Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor.

Publication ,  Journal Article
Ishikawa, J; Shimizu, M; Sugiyama Edison, E; Yano, Y; Hoshide, S; Eguchi, K; Kario, K ...
Published in: J Hypertens
January 2014

BACKGROUND: Night-time blood pressure (BP) is strongly associated with hypertensive target organ damage; however, no previous studies have compared home BP monitor measurements of the reduction in night-time BP induced by antihypertensive medications with those obtained with ambulatory BP monitors. METHODS: As part of the Japan Morning Surge-Target Organ Protection study, in which candesartan (thiazide diuretics were added, if needed) was administered to hypertensive patients in the morning or at bedtime, 50 hypertensive patients had their night-time home and ambulatory BP successfully measured at the baseline and 6 months. In addition, three night-time home BP readings were taken during sleeping hours (at 2, 3, and 4 o'clock) for 6 months. RESULTS: The mean reduction in night-time BP did not differ significantly between home and ambulatory BP monitoring (10.4 ± 17.9/6.0 ± 12.0 vs. 13.3 ± 14.6/7.6 ± 8.9 mmHg, P = 0.219/0.344), but the differences varied among individual patients. The reduction in night-time BP according to home BP monitoring was significantly correlated with the value obtained with ambulatory BP monitoring (r = 0.51/0.38, P < 0.001/=0.006). The reduction in night-time SBP according to home BP monitoring was significantly correlated with the reductions in left ventricular mass index (r = 0.385, P = 0.013, N = 41) and Sokolow-Lyon voltage (r = 0.335, P = 0.035, N = 40). CONCLUSION: Home BP monitoring produces estimates of mean night-time BP reductions comparable to those from ambulatory monitoring, while the differences varied among individual patients. The reduction in night-time home BP according to home BP monitoring is significantly correlated with the reduction in left ventricular hypertrophy.

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Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

January 2014

Volume

32

Issue

1

Start / End Page

82 / 89

Location

Netherlands

Related Subject Headings

  • Middle Aged
  • Male
  • Japan
  • Hypertension
  • Humans
  • Female
  • Electrocardiography
  • Echocardiography
  • Circadian Rhythm
  • Cardiovascular System & Hematology
 

Citation

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Ishikawa, J., Shimizu, M., Sugiyama Edison, E., Yano, Y., Hoshide, S., Eguchi, K., … J-TOP (Japan Morning Surge-Target Organ Protection) Study Investigators Group, . (2014). Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. J Hypertens, 32(1), 82–89. https://doi.org/10.1097/HJH.0b013e328365c8a8
Ishikawa, Joji, Motohiro Shimizu, Eijiro Sugiyama Edison, Yuichiro Yano, Satoshi Hoshide, Kauzo Eguchi, Kazuomi Kario, and Kazuomi J-TOP (Japan Morning Surge-Target Organ Protection) Study Investigators Group. “Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor.J Hypertens 32, no. 1 (January 2014): 82–89. https://doi.org/10.1097/HJH.0b013e328365c8a8.
Ishikawa J, Shimizu M, Sugiyama Edison E, Yano Y, Hoshide S, Eguchi K, et al. Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. J Hypertens. 2014 Jan;32(1):82–9.
Ishikawa, Joji, et al. “Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor.J Hypertens, vol. 32, no. 1, Jan. 2014, pp. 82–89. Pubmed, doi:10.1097/HJH.0b013e328365c8a8.
Ishikawa J, Shimizu M, Sugiyama Edison E, Yano Y, Hoshide S, Eguchi K, Kario K, J-TOP (Japan Morning Surge-Target Organ Protection) Study Investigators Group. Assessment of the reductions in night-time blood pressure and dipping induced by antihypertensive medication using a home blood pressure monitor. J Hypertens. 2014 Jan;32(1):82–89.

Published In

J Hypertens

DOI

EISSN

1473-5598

Publication Date

January 2014

Volume

32

Issue

1

Start / End Page

82 / 89

Location

Netherlands

Related Subject Headings

  • Middle Aged
  • Male
  • Japan
  • Hypertension
  • Humans
  • Female
  • Electrocardiography
  • Echocardiography
  • Circadian Rhythm
  • Cardiovascular System & Hematology