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Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis.

Publication ,  Journal Article
Iwakiri, T; Yano, Y; Sato, Y; Hatakeyama, K; Marutsuka, K; Fujimoto, S; Kitamura, K; Kario, K; Asada, Y
Published in: Atherosclerosis
December 2012

BACKGROUND: Ultrasound-determined carotid intima-media thickness (IMT) is widely used as an indicator of generalized atherosclerotic burden, but there are limited autopsy findings in support of the association, directly. METHODS: We performed an autopsy analysis (n = 111, mean 68.8 years; 65.0% men; 86% non-cardiovascular disease death) to examine the associations of microscopy-determined carotid IMT including plaque thickness with the severity of atherosclerosis in the generalized arteries. RESULTS: Microscopy-determined carotid IMT was associated with the extent of intima/media layer ratio of the vasculature, a marker of atherosclerosis, in each structure examined, i.e., coronary artery, cerebrovasculature, thoracic aorta, abdominal aorta, and iliac artery (R = 0.31-0.42; all P < 0.01). The prevalence of a necrotic core in the coronary artery, cerebrovasculature, thoracic aorta, abdominal aorta, and iliac artery increased in accordance with increasing microscopy-determined carotid IMT (all P < 0.05). CONCLUSION: Our autopsy analysis confirms the validity of carotid IMT including plaque thickness as an indicator of generalized atherosclerosis.

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Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

December 2012

Volume

225

Issue

2

Start / End Page

359 / 362

Location

Ireland

Related Subject Headings

  • Severity of Illness Index
  • Reproducibility of Results
  • Predictive Value of Tests
  • Plaque, Atherosclerotic
  • Necrosis
  • Middle Aged
  • Male
  • Intracranial Arteriosclerosis
  • Iliac Artery
  • Humans
 

Citation

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Iwakiri, T., Yano, Y., Sato, Y., Hatakeyama, K., Marutsuka, K., Fujimoto, S., … Asada, Y. (2012). Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. Atherosclerosis, 225(2), 359–362. https://doi.org/10.1016/j.atherosclerosis.2012.10.033
Iwakiri, Takashi, Yuichiro Yano, Yuichiro Sato, Kinta Hatakeyama, Kousuke Marutsuka, Shouichi Fujimoto, Kazuo Kitamura, Kazuomi Kario, and Yujiro Asada. “Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis.Atherosclerosis 225, no. 2 (December 2012): 359–62. https://doi.org/10.1016/j.atherosclerosis.2012.10.033.
Iwakiri T, Yano Y, Sato Y, Hatakeyama K, Marutsuka K, Fujimoto S, et al. Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. Atherosclerosis. 2012 Dec;225(2):359–62.
Iwakiri, Takashi, et al. “Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis.Atherosclerosis, vol. 225, no. 2, Dec. 2012, pp. 359–62. Pubmed, doi:10.1016/j.atherosclerosis.2012.10.033.
Iwakiri T, Yano Y, Sato Y, Hatakeyama K, Marutsuka K, Fujimoto S, Kitamura K, Kario K, Asada Y. Usefulness of carotid intima-media thickness measurement as an indicator of generalized atherosclerosis: findings from autopsy analysis. Atherosclerosis. 2012 Dec;225(2):359–362.
Journal cover image

Published In

Atherosclerosis

DOI

EISSN

1879-1484

Publication Date

December 2012

Volume

225

Issue

2

Start / End Page

359 / 362

Location

Ireland

Related Subject Headings

  • Severity of Illness Index
  • Reproducibility of Results
  • Predictive Value of Tests
  • Plaque, Atherosclerotic
  • Necrosis
  • Middle Aged
  • Male
  • Intracranial Arteriosclerosis
  • Iliac Artery
  • Humans