Skip to main content
Journal cover image

Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives.

Publication ,  Journal Article
Hayakawa, M; Yano, Y; Kuroki, K; Inoue, R; Nakanishi, C; Sagara, S; Koga, M; Kubo, H; Imakiire, S; Aoyagi, Z; Kitani, M; Kanemaru, K ...
Published in: Am J Hypertens
June 2012

BACKGROUND: Our aim was to assess whether cardiac hypertrophy is associated with cognitive function independently of office, 24-h, or sleep blood pressure (BP) levels in older hypertensive patients treated with antihypertensive medications. METHODS: In this cross-sectional study, we recruited 443 hypertensive patients aged over 60 years (mean age: 73.0 years; 41% men) who were ambulatory, lived independently, and were without clinically overt dementia. They underwent measurements of 24-h BP monitoring, echocardiographic left ventricular mass index (LVMI), and cognitive function (mini-mental state examination, MMSE). RESULTS: MMSE score was inversely associated with office, 24-h, awake, and sleep systolic BP (SBP) (each, P < 0.05). There was a close association between MMSE score and LVMI (ρ = -0.32; P < 0.001). Using multiple logistic regression analysis including numerous covariates (i.e., age, sex, obesity, current smoking, educational level, duration of antihypertensive medications, renal dysfunction, statin use, and previous history of cardiovascular disease), the odds ratio (OR) for the presence of cognitive dysfunction, defined as the lowest quartile of MMSE score (median MMSE score: 23 points; n = 115), was estimated; the presence of cardiac hypertrophy (LVMI ≥125 kg/m(2) in men and ≥110 kg/m(2) in women) as well as uncontrolled 24-h BP (mean 24-h SBP/diastolic BP (DBP) ≥130/80 mm Hg) or sleep BP (mean sleep SBP/DBP ≥120/70 mm Hg), but not uncontrolled office BP (mean office SBP/DBP ≥140/90 mm Hg), were independently associated with cognitive dysfunction (all P < 0.05). CONCLUSIONS: Among older hypertensive patients with antihypertensive medications, those who had echocardiographically determined cardiac hypertrophy may be at high risk for cognitive dysfunction, irrespective of their office BP and 24-h BP levels.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

June 2012

Volume

25

Issue

6

Start / End Page

657 / 663

Location

United States

Related Subject Headings

  • Sleep
  • Risk Factors
  • Office Visits
  • Male
  • Logistic Models
  • Intelligence Tests
  • Hypertension
  • Humans
  • Heart Ventricles
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hayakawa, M., Yano, Y., Kuroki, K., Inoue, R., Nakanishi, C., Sagara, S., … Kario, K. (2012). Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives. Am J Hypertens, 25(6), 657–663. https://doi.org/10.1038/ajh.2012.27
Hayakawa, Manabu, Yuichiro Yano, Kazuo Kuroki, Ryuji Inoue, Chihiro Nakanishi, Seiji Sagara, Masahiro Koga, et al. “Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives.Am J Hypertens 25, no. 6 (June 2012): 657–63. https://doi.org/10.1038/ajh.2012.27.
Hayakawa M, Yano Y, Kuroki K, Inoue R, Nakanishi C, Sagara S, et al. Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives. Am J Hypertens. 2012 Jun;25(6):657–63.
Hayakawa, Manabu, et al. “Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives.Am J Hypertens, vol. 25, no. 6, June 2012, pp. 657–63. Pubmed, doi:10.1038/ajh.2012.27.
Hayakawa M, Yano Y, Kuroki K, Inoue R, Nakanishi C, Sagara S, Koga M, Kubo H, Imakiire S, Aoyagi Z, Kitani M, Kanemaru K, Hidehito S, Shimada K, Kario K. Independent association of cognitive dysfunction with cardiac hypertrophy irrespective of 24-h or sleep blood pressure in older hypertensives. Am J Hypertens. 2012 Jun;25(6):657–663.
Journal cover image

Published In

Am J Hypertens

DOI

EISSN

1941-7225

Publication Date

June 2012

Volume

25

Issue

6

Start / End Page

657 / 663

Location

United States

Related Subject Headings

  • Sleep
  • Risk Factors
  • Office Visits
  • Male
  • Logistic Models
  • Intelligence Tests
  • Hypertension
  • Humans
  • Heart Ventricles
  • Female