Differential impacts of adiponectin on low-grade albuminuria between obese and nonobese persons without diabetes.

Published

Journal Article

The goal of this study was to examine the association between adiponectin and low-grade albuminuria in nondiabetic persons and whether it differed between obese and nonobese individuals. Urinary albumin excretion (UAE) was assessed by overnight collection in 157 participants. Overall, as anticipated, 24-hour systolic blood pressure and fasting glucose levels were independent determinants of UAE (beta=0.254 and 0.176, respectively, P<.05). In obese persons (body mass index [BMI] >/=25 kg/m(2); n=63), adiponectin value was a significant negative determinant of UAE (beta=-0.256, P<.05) independent of blood pressure and glucose levels, whereas in nonobese participants (n=94) it was not. In an analysis of BMI and the median value of adiponectin (9.9 microg/mL), UAE was found to be significantly higher in obese persons with low adiponectin levels than in obese persons with high adiponectin levels (9.20 vs 5.11 microg/min; P<.05), even after adjustment for age, sex, blood pressure level, and glucose level. There was an inverse association between adiponectin and low-grade albuminuria in obese nondiabetic persons.

Full Text

Duke Authors

Cited Authors

  • Yano, Y; Hoshide, S; Ishikawa, J; Hashimoto, T; Eguchi, K; Shimada, K; Kario, K

Published Date

  • October 2007

Published In

Volume / Issue

  • 9 / 10

Start / End Page

  • 775 - 782

PubMed ID

  • 17917505

Pubmed Central ID

  • 17917505

International Standard Serial Number (ISSN)

  • 1524-6175

Digital Object Identifier (DOI)

  • 10.1111/j.1524-6175.2007.07321.x

Language

  • eng

Conference Location

  • United States