Skip to main content

Interphase cohesin regulation ensures mitotic fidelity after genome reduplication.

Publication ,  Journal Article
Stormo, BM; Fox, DT
Published in: Mol Biol Cell
January 15, 2019

To ensure faithful genome propagation, mitotic cells alternate one round of chromosome duplication with one round of chromosome separation. Chromosome separation failure thus causes genome reduplication, which alters mitotic chromosome structure. Such structural alterations are well documented to impair mitotic fidelity following aberrant genome reduplication, including in diseased states. In contrast, we recently showed that naturally occurring genome reduplication does not alter mitotic chromosome structure in Drosophila papillar cells. Our discovery raised the question of how a cell undergoing genome reduplication might regulate chromosome structure to prevent mitotic errors. Here, we show that papillar cells ensure mitotic fidelity through interphase cohesin regulation. We demonstrate a requirement for cohesins during programmed rounds of papillar genome reduplication known as endocycles. This interphase cohesin regulation relies on cohesin release but not cohesin cleavage and depends on the conserved cohesin regulator Pds5 . Our data suggest that a distinct form of interphase cohesin regulation ensures mitotic fidelity after genome reduplication.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Mol Biol Cell

DOI

EISSN

1939-4586

Publication Date

January 15, 2019

Volume

30

Issue

2

Start / End Page

219 / 227

Location

United States

Related Subject Headings

  • Mitosis
  • Interphase
  • Genome, Insect
  • Gene Duplication
  • Drosophila melanogaster
  • Drosophila Proteins
  • Developmental Biology
  • Cohesins
  • Chromosomes
  • Chromosomal Proteins, Non-Histone
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Stormo, B. M., & Fox, D. T. (2019). Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. Mol Biol Cell, 30(2), 219–227. https://doi.org/10.1091/mbc.E17-10-0582
Stormo, Benjamin M., and Donald T. Fox. “Interphase cohesin regulation ensures mitotic fidelity after genome reduplication.Mol Biol Cell 30, no. 2 (January 15, 2019): 219–27. https://doi.org/10.1091/mbc.E17-10-0582.
Stormo BM, Fox DT. Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. Mol Biol Cell. 2019 Jan 15;30(2):219–27.
Stormo, Benjamin M., and Donald T. Fox. “Interphase cohesin regulation ensures mitotic fidelity after genome reduplication.Mol Biol Cell, vol. 30, no. 2, Jan. 2019, pp. 219–27. Pubmed, doi:10.1091/mbc.E17-10-0582.
Stormo BM, Fox DT. Interphase cohesin regulation ensures mitotic fidelity after genome reduplication. Mol Biol Cell. 2019 Jan 15;30(2):219–227.

Published In

Mol Biol Cell

DOI

EISSN

1939-4586

Publication Date

January 15, 2019

Volume

30

Issue

2

Start / End Page

219 / 227

Location

United States

Related Subject Headings

  • Mitosis
  • Interphase
  • Genome, Insect
  • Gene Duplication
  • Drosophila melanogaster
  • Drosophila Proteins
  • Developmental Biology
  • Cohesins
  • Chromosomes
  • Chromosomal Proteins, Non-Histone