A trichogenic tumor with aggressive features initially diagnosed as basal cell carcinoma.

Published online

Journal Article

Trichoblastic carcinoma is a rare carcinoma often arising in a pre-existing trichoblastoma. It may resemble basal cell carcinoma, posing a diagnostic challenge. Trichoblastic carcinoma is divided into low-grade and high-grade tumors. Low-grade tumors resemble basal cell carcinomas and are therefore synonymous in some classifications. High-grade tumors, which commonly present on the scalp in older individuals or in patients with Brooke-Spiegler syndrome, have been associated with a higher potential for distant metastasis and death. We present a case in which a 73-year-old female had a long-standing scalp nodule for over 30 years that rapidly increased in size. The patient's lesion was initially diagnosed as basal cell carcinoma on shave biopsy, but upon excision, revealed features concerning for trichoblastic carcinoma such as brisk mitotic activity and comedo-like necrosis. Sudden change in an atypical scalp lesion that has been present for many years should increase suspicion for an atypical trichogenic tumor, such as trichoblastic carcinoma.

Full Text

Duke Authors

Cited Authors

  • Kwock, JT; Casady, M; Handfield, C; MacLeod, AS; Pavlis, MB

Published Date

  • September 15, 2018

Published In

Volume / Issue

  • 24 / 9

PubMed ID

  • 30677834

Pubmed Central ID

  • 30677834

Electronic International Standard Serial Number (EISSN)

  • 1087-2108

Language

  • eng

Conference Location

  • United States