Pancreas Transplantation: Indications, Techniques, and Outcomes.

Journal Article (Journal Article;Review)

Pancreas transplantation treats insulin-dependent diabetes with or without concurrent end-stage renal disease. Pancreas transplantation increases survival versus no transplant, increases survival when performed as simultaneous pancreas-kidney versus deceased-donor kidney alone, and improves quality of life. Careful donor and recipient selection are paramount to good outcomes. Several technical variations exist for implantation: portal versus systemic vascular drainage and jejunal versus duodenal versus bladder exocrine drainage. Complications are most frequently technical in the first year and immunologic thereafter. Graft rejection is challenging to diagnose and is treated selectively. Islet cell transplantation currently has inferior outcomes to whole-organ pancreas transplantation.

Full Text

Duke Authors

Cited Authors

  • Samoylova, ML; Borle, D; Ravindra, KV

Published Date

  • February 2019

Published In

Volume / Issue

  • 99 / 1

Start / End Page

  • 87 - 101

PubMed ID

  • 30471744

Electronic International Standard Serial Number (EISSN)

  • 1558-3171

Digital Object Identifier (DOI)

  • 10.1016/j.suc.2018.09.007


  • eng

Conference Location

  • United States