Pancreas Transplantation: Indications, Techniques, and Outcomes.
Pancreas transplantation treats insulin-dependent diabetes with or without concurrent end-stage renal disease. Pancreas transplantation increases survival versus no transplant, increases survival when performed as simultaneous pancreas-kidney versus deceased-donor kidney alone, and improves quality of life. Careful donor and recipient selection are paramount to good outcomes. Several technical variations exist for implantation: portal versus systemic vascular drainage and jejunal versus duodenal versus bladder exocrine drainage. Complications are most frequently technical in the first year and immunologic thereafter. Graft rejection is challenging to diagnose and is treated selectively. Islet cell transplantation currently has inferior outcomes to whole-organ pancreas transplantation.
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Related Subject Headings
- Treatment Outcome
- Surgery
- Postoperative Complications
- Patient Selection
- Pancreas Transplantation
- Humans
- Graft Survival
- Graft Rejection
- 3202 Clinical sciences
- 1103 Clinical Sciences
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Treatment Outcome
- Surgery
- Postoperative Complications
- Patient Selection
- Pancreas Transplantation
- Humans
- Graft Survival
- Graft Rejection
- 3202 Clinical sciences
- 1103 Clinical Sciences