ATAC-ing the mechanisms of renin regulation.

Journal Article (Journal Article)

Renin-expressing cells have been conserved through evolution and maintain blood pressure and fluid homeostasis. Lack of availability of tools to study the specifics of renin regulation has limited advances in this field. In the current issue of the Journal of Clinical Investigation, Martinez and colleagues used the genome-wide assessment of the chromatin status of cells and uncovered a unique set of super-enhancers that determine the identity of renin cells. The renin super-enhancers play a key role in the molecular memory of renin cell function, a mechanism at the core of preserving homeostasis.

Full Text

Duke Authors

Cited Authors

  • Crowley, SD

Published Date

  • November 1, 2018

Published In

Volume / Issue

  • 128 / 11

Start / End Page

  • 4748 - 4750

PubMed ID

  • 30277477

Pubmed Central ID

  • PMC6205367

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI124177

Language

  • eng

Conference Location

  • United States