Are Neuropeptide-Reactive T Cells behind Narcolepsy?


Journal Article

Researchers have previously hypothesized autoimmune origins for narcolepsy on the basis of its strong genetic association with an MHC class II allele. In a recent issue of Nature, Latorre et al. (2018) discovered that narcolepsy patients had autoreactive T cells specific to the neuronal antigen hypocretin, providing more evidence of the potential immune origin of the disease.

Full Text

Duke Authors

Cited Authors

  • Deerhake, ME; Barclay, WE; Shinohara, ML

Published Date

  • November 20, 2018

Published In

Volume / Issue

  • 49 / 5

Start / End Page

  • 796 - 798

PubMed ID

  • 30462995

Pubmed Central ID

  • 30462995

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

Digital Object Identifier (DOI)

  • 10.1016/j.immuni.2018.11.002


  • eng

Conference Location

  • United States