A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.

Journal Article (Journal Article)

Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.

Full Text

Duke Authors

Cited Authors

  • Kleinbart, JE; Orsborn, AL; Choi, JS; Wang, C; Qiao, S; Viventi, J; Pesaran, B

Published Date

  • July 2018

Published In

  • Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual International Conference

Volume / Issue

  • 2018 /

Start / End Page

  • 3362 - 3365

PubMed ID

  • 30441108

Pubmed Central ID

  • PMC7401970

Electronic International Standard Serial Number (EISSN)

  • 2694-0604

International Standard Serial Number (ISSN)

  • 2375-7477

Digital Object Identifier (DOI)

  • 10.1109/embc.2018.8512993

Language

  • eng