Pre-ictal seizure detection and demand treatment strategies for epilepsy

Published

Book Section

© 2005 by CRC Press LLC. Mechanisms of epilepsy have been explored through a variety of animal models as well as detailed human studies, for more than 70 years.1-3 Through the animal models, a large number of contributing factors leading to epilepsy have been demonstrated, including conditions that lead to the intermittent, enhanced synchrony leading to partial or generalized seizures. While animal models still have only moderate predictive validity for anticonvulsant therapy development, the mechanisms may potentially apply to the human situation. However, in general, most animal models involve acute seizure development, mirrored in humans as acute convulsions, usually due to systemic or CNS irritants or toxins. For example, a classic convulsion may be seen with an overdose of penicillin or meperidine, and convulsions are characterized by a high degree of neuronal electrical synchrony throughout the brain.

Duke Authors

Cited Authors

  • Turner, DA; Nicolelis, MAL; van Landingham, K

Published Date

  • January 1, 2004

Book Title

  • Modern Neurosurgery: Clinical Translation of Neuroscience Advances

Start / End Page

  • 105 - 118

International Standard Book Number 10 (ISBN-10)

  • 0849314828

International Standard Book Number 13 (ISBN-13)

  • 9780849314827

Citation Source

  • Scopus