Safety in Acute Pain Medicine-Pharmacologic Considerations and the Impact of Systems-Based Gaps.

Journal Article (Journal Article)

Objective: In the setting of an expanding prevalence of acute pain medicine services and the aggressive use of multimodal analgesia, an overview of systems-based safety gaps and safety concerns in the setting of aggressive multimodal analgesia is provided below. Setting: Expert commentary. Methods: Recent evidence focused on systems-based gaps in acute pain medicine is discussed. A focused literature review was conducted to assess safety concerns related to commonly used multimodal pharmacologic agents (opioids, nonsteroidal anti-inflammatory drugs, gabapentanoids, ketamine, acetaminophen) in the setting of inpatient acute pain management. Conclusions: Optimization of systems-based gaps will increase the probability of accurate pain assessment, improve the application of uniform evidence-based multimodal analgesia, and ensure a continuum of pain care. While acute pain medicine strategies should be aggressively applied, multimodal regimens must be strategically utilized to minimize risk to patients and in a comorbidity-specific fashion.

Full Text

Duke Authors

Cited Authors

  • Weingarten, TN; Taenzer, AH; Elkassabany, NM; Le Wendling, L; Nin, O; Kent, ML

Published Date

  • November 1, 2018

Published In

Volume / Issue

  • 19 / 11

Start / End Page

  • 2296 - 2315

PubMed ID

  • 29727003

Electronic International Standard Serial Number (EISSN)

  • 1526-4637

Digital Object Identifier (DOI)

  • 10.1093/pm/pny079


  • eng

Conference Location

  • England