Interethnic analyses of blood pressure loci in populations of East Asian and European descent.
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP.
Takeuchi, F; Akiyama, M; Matoba, N; Katsuya, T; Nakatochi, M; Tabara, Y; Narita, A; Saw, W-Y; Moon, S; Spracklen, CN; Chai, J-F; Kim, Y-J; Zhang, L; Wang, C; Li, H; Li, H; Wu, J-Y; Dorajoo, R; Nierenberg, JL; Wang, YX; He, J; Bennett, DA; Takahashi, A; Momozawa, Y; Hirata, M; Matsuda, K; Rakugi, H; Nakashima, E; Isono, M; Shirota, M; Hozawa, A; Ichihara, S; Matsubara, T; Yamamoto, K; Kohara, K; Igase, M; Han, S; Gordon-Larsen, P; Huang, W; Lee, NR; Adair, LS; Hwang, MY; Lee, J; Chee, ML; Sabanayagam, C; Zhao, W; Liu, J; Reilly, DF; Sun, L; Huo, S; Edwards, TL; Long, J; Chang, L-C; Chen, C-H; Yuan, J-M; Koh, W-P; Friedlander, Y; Kelly, TN; Bin Wei, W; Xu, L; Cai, H; Xiang, Y-B; Lin, K; Clarke, R; Walters, RG; Millwood, IY; Li, L; Chambers, JC; Kooner, JS; Elliott, P; van der Harst, P; International Genomics of Blood Pressure (iGEN-BP) Consortium, ; Chen, Z; Sasaki, M; Shu, X-O; Jonas, JB; He, J; Heng, C-K; Chen, Y-T; Zheng, W; Lin, X; Teo, Y-Y; Tai, E-S; Cheng, C-Y; Wong, TY; Sim, X; Mohlke, KL; Yamamoto, M; Kim, B-J; Miki, T; Nabika, T; Yokota, M; Kamatani, Y; Kubo, M; Kato, N
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