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Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Publication ,  Journal Article
Walters, RK; Polimanti, R; Johnson, EC; McClintick, JN; Adams, MJ; Adkins, AE; Aliev, F; Bacanu, S-A; Batzler, A; Bertelsen, S; Biernacka, JM ...
Published in: Nat Neurosci
December 2018

Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic relationship with other disorders. To discover loci associated with AD and characterize the relationship between AD and other psychiatric and behavioral outcomes, we carried out the largest genome-wide association study to date of DSM-IV-diagnosed AD. Genome-wide data on 14,904 individuals with AD and 37,944 controls from 28 case-control and family-based studies were meta-analyzed, stratified by genetic ancestry (European, n = 46,568; African, n = 6,280). Independent, genome-wide significant effects of different ADH1B variants were identified in European (rs1229984; P = 9.8 × 10-13) and African ancestries (rs2066702; P = 2.2 × 10-9). Significant genetic correlations were observed with 17 phenotypes, including schizophrenia, attention deficit-hyperactivity disorder, depression, and use of cigarettes and cannabis. The genetic underpinnings of AD only partially overlap with those for alcohol consumption, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.

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Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

December 2018

Volume

21

Issue

12

Start / End Page

1656 / 1669

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Phenotype
  • Neurology & Neurosurgery
  • Mental Disorders
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Alleles
  • Alcoholism
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Walters, R. K., Polimanti, R., Johnson, E. C., McClintick, J. N., Adams, M. J., Adkins, A. E., … Agrawal, A. (2018). Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci, 21(12), 1656–1669. https://doi.org/10.1038/s41593-018-0275-1
Walters, Raymond K., Renato Polimanti, Emma C. Johnson, Jeanette N. McClintick, Mark J. Adams, Amy E. Adkins, Fazil Aliev, et al. “Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.Nat Neurosci 21, no. 12 (December 2018): 1656–69. https://doi.org/10.1038/s41593-018-0275-1.
Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, et al. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 Dec;21(12):1656–69.
Walters, Raymond K., et al. “Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.Nat Neurosci, vol. 21, no. 12, Dec. 2018, pp. 1656–69. Pubmed, doi:10.1038/s41593-018-0275-1.
Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu S-A, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen L-S, Clarke T-K, Chou Y-L, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang J-C, Webb BT, Wedow R, Wetherill L, Wills AG, 23andMe Research Team, Boardman JD, Chen D, Choi D-S, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen P-H, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nat Neurosci. 2018 Dec;21(12):1656–1669.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

December 2018

Volume

21

Issue

12

Start / End Page

1656 / 1669

Location

United States

Related Subject Headings

  • Polymorphism, Single Nucleotide
  • Phenotype
  • Neurology & Neurosurgery
  • Mental Disorders
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
  • Alleles
  • Alcoholism