Relationship between diffusion capacity and small airway abnormality in COPDGene.
Conference Paper
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.
Full Text
Duke Authors
Cited Authors
- Criner, RN; Hatt, CR; Galbán, CJ; Kazerooni, EA; Lynch, DA; McCormack, MC; Casaburi, R; MacIntyre, NR; Make, BJ; Martinez, FJ; Labaki, WW; Curtis, JL; Han, MLK
Published Date
- December 2, 2019
Published In
Volume / Issue
- 20 / 1
Start / End Page
- 269 -
PubMed ID
- 31791337
Pubmed Central ID
- PMC6889734
Electronic International Standard Serial Number (EISSN)
- 1465-993X
Digital Object Identifier (DOI)
- 10.1186/s12931-019-1237-1
Conference Location
- England