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Relationship between diffusion capacity and small airway abnormality in COPDGene.

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Criner, RN; Hatt, CR; Galbán, CJ; Kazerooni, EA; Lynch, DA; McCormack, MC; Casaburi, R; MacIntyre, NR; Make, BJ; Martinez, FJ; Labaki, WW ...
Published in: Respir Res
December 2, 2019

Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.

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Published In

Respir Res

DOI

EISSN

1465-993X

Publication Date

December 2, 2019

Volume

20

Issue

1

Start / End Page

269

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Severity of Illness Index
  • Retrospective Studies
  • Respiratory System
  • Respiratory Function Tests
  • Regression Analysis
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Diffusing Capacity
  • Multivariate Analysis
 

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Criner, R. N., Hatt, C. R., Galbán, C. J., Kazerooni, E. A., Lynch, D. A., McCormack, M. C., … Han, M. L. K. (2019). Relationship between diffusion capacity and small airway abnormality in COPDGene. In Respir Res (Vol. 20, p. 269). England. https://doi.org/10.1186/s12931-019-1237-1
Criner, Rachel N., Charles R. Hatt, Craig J. Galbán, Ella A. Kazerooni, David A. Lynch, Meredith C. McCormack, Richard Casaburi, et al. “Relationship between diffusion capacity and small airway abnormality in COPDGene.” In Respir Res, 20:269, 2019. https://doi.org/10.1186/s12931-019-1237-1.
Criner RN, Hatt CR, Galbán CJ, Kazerooni EA, Lynch DA, McCormack MC, et al. Relationship between diffusion capacity and small airway abnormality in COPDGene. In: Respir Res. 2019. p. 269.
Criner, Rachel N., et al. “Relationship between diffusion capacity and small airway abnormality in COPDGene.Respir Res, vol. 20, no. 1, 2019, p. 269. Pubmed, doi:10.1186/s12931-019-1237-1.
Criner RN, Hatt CR, Galbán CJ, Kazerooni EA, Lynch DA, McCormack MC, Casaburi R, MacIntyre NR, Make BJ, Martinez FJ, Labaki WW, Curtis JL, Han MLK. Relationship between diffusion capacity and small airway abnormality in COPDGene. Respir Res. 2019. p. 269.

Published In

Respir Res

DOI

EISSN

1465-993X

Publication Date

December 2, 2019

Volume

20

Issue

1

Start / End Page

269

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Severity of Illness Index
  • Retrospective Studies
  • Respiratory System
  • Respiratory Function Tests
  • Regression Analysis
  • Pulmonary Emphysema
  • Pulmonary Disease, Chronic Obstructive
  • Pulmonary Diffusing Capacity
  • Multivariate Analysis