Relationship between diffusion capacity and small airway abnormality in COPDGene.
Impaired single breath carbon monoxide diffusing capacity (DLCO) is associated with emphysema. Small airways disease (SAD) may be a precursor lesion to emphysema, but the relationship between SAD and DLCO is undescribed. We hypothesized that in mild COPD, functional SAD (fSAD) defined by computed tomography (CT) and Parametric Response Mapping methodology would correlate with impaired DLCO. Using data from ever-smokers in the COPDGene cohort, we established that fSAD correlated significantly with lower DLCO among both non-obstructed and GOLD 1-2 subjects. The relationship between DLCO with CT-defined emphysema was present in all GOLD stages, but most prominent in severe disease. TRIAL REGISTRATION: NCT00608764. Registry: COPDGene. Registered 06 February 2008, retrospectively registered.
Duke Scholars
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Related Subject Headings
- Tomography, X-Ray Computed
- Severity of Illness Index
- Retrospective Studies
- Respiratory System
- Respiratory Function Tests
- Regression Analysis
- Pulmonary Emphysema
- Pulmonary Disease, Chronic Obstructive
- Pulmonary Diffusing Capacity
- Multivariate Analysis
Citation
Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tomography, X-Ray Computed
- Severity of Illness Index
- Retrospective Studies
- Respiratory System
- Respiratory Function Tests
- Regression Analysis
- Pulmonary Emphysema
- Pulmonary Disease, Chronic Obstructive
- Pulmonary Diffusing Capacity
- Multivariate Analysis