Granular hydrogels: emergent properties of jammed hydrogel microparticles and their applications in tissue repair and regeneration.

Published

Journal Article (Review)

Granular hydrogels are emerging as a versatile and effective platform for tissue engineered constructs in regenerative medicine. The hydrogel microparticles (HMPs) that compose these materials exhibit particle jamming above a minimum packing fraction, which results in a bulk, yet dynamic, granular hydrogel scaffold. These injectable, microporous scaffolds possess self-assembling, shear-thinning, and self-healing properties. Recently, they have been utilized as cell cultures platforms and extracellular matrix mimics with remarkable success in promoting cellular infiltration and subsequent tissue remodeling in vivo. Furthermore, the modular nature of granular hydrogels accommodates heterogeneous HMP assembly, where varying HMPs have been fabricated to target distinct biological processes or deliver unique cargo. Such multifunctional materials offer enormous potential for capturing the structural and biofunctional complexity observed in native human tissue.

Full Text

Duke Authors

Cited Authors

  • Riley, L; Schirmer, L; Segura, T

Published Date

  • November 24, 2018

Published In

Volume / Issue

  • 60 /

Start / End Page

  • 1 - 8

PubMed ID

  • 30481603

Pubmed Central ID

  • 30481603

Electronic International Standard Serial Number (EISSN)

  • 1879-0429

International Standard Serial Number (ISSN)

  • 0958-1669

Digital Object Identifier (DOI)

  • 10.1016/j.copbio.2018.11.001

Language

  • eng