T-Cell migration across the blood-brain barrier in CNS inflammatory diseases

Book Section

T-cell migration into the central nervous system (CNS) is a critical element in infiammatory and autoimmune diseases of the nervous tissue. Although several components involved in this process have been identified, we still lack a complete understanding of the initiation of CNS immune reactivity and T-cell recruitment into the CNS. Elucidating the pathways that promote T-cell migration and recruitment into the CNS is therefore necessary in order to gain an understanding of CNS immune reactivity and to design novel immune therapies that interfere with infiammatory and autoimmune diseases of the CNS.

Duke Authors

Cited Authors

  • Fabry, Z; Reinke, E; Karman, J

Published Date

  • January 1, 2005

Book Title

  • The Blood-Brain Barrier and its Microenvironment: Basic Physiology to Neurological Disease

Start / End Page

  • 193 - 242

International Standard Book Number 13 (ISBN-13)

  • 9780849398926

Citation Source

  • Scopus