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Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.

Publication ,  Journal Article
Jung, N-Y; Han, JC; Ong, YT; Cheung, CY-L; Chen, CP; Wong, TY; Kim, HJ; Kim, YJ; Lee, J; Lee, JS; Jang, YK; Kee, C; Lee, KH; Kim, E-J; Seo, SW; Na, DL
Published in: J Neurol Sci
January 15, 2019

BACKGROUND AND PURPOSE: To investigate small vessel abnormalities in patients with cognitive impairment, we compared retinal microvascular alterations between patients with cognitive impairment related to Alzheimer's disease (ADCI) and those with subcortical vascular cognitive impairment (SVCI). METHODS: We prospectively recruited 29 amyloid-positive ADCI patients, 28 amyloid-negative SVCI patients that were confirmed by 11C-PiB-PET scan and 34 individuals with normal cognition (NC). The three groups were compared in terms of retinal vascular variables (retinal fractal dimension, vascular caliber, tortuosity and branching angle) by using a semi-automated, computer-assisted analysis of digital fundus photographs. We also investigated the relationship between retinal variables and white matter hyperintensities (WMH) on MRI. RESULTS: Compared to NC individuals, the SVCI patients had smaller total and arteriolar fractal dimensions, whereas there was no significant difference of fractal dimension between ADCI and NC. Other retinal variables did not differ among the three groups. A significant correlation existed between fractal dimension and WMH volume. CONCLUSIONS: Retinal microvascular alterations, especially retinal fractal dimension, may be useful markers that reflect cerebral microvascular changes in patients with SVCI as opposed to ADCI, who had no definite difference in retinal variables compared to the NC group.

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Published In

J Neurol Sci

DOI

EISSN

1878-5883

Publication Date

January 15, 2019

Volume

396

Start / End Page

94 / 101

Location

Netherlands

Related Subject Headings

  • White Matter
  • Thiazoles
  • Risk Factors
  • Retina
  • Positron-Emission Tomography
  • Neuropsychological Tests
  • Middle Aged
  • Microvessels
  • Male
  • Magnetic Resonance Imaging
 

Citation

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Jung, N.-Y., Han, J. C., Ong, Y. T., Cheung, C.-L., Chen, C. P., Wong, T. Y., … Na, D. L. (2019). Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease. J Neurol Sci, 396, 94–101. https://doi.org/10.1016/j.jns.2018.10.025
Jung, Na-Yeon, Jong Chul Han, Yi Ting Ong, Carol Yim-Lui Cheung, Christopher P. Chen, Tien Yin Wong, Hee Jin Kim, et al. “Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.J Neurol Sci 396 (January 15, 2019): 94–101. https://doi.org/10.1016/j.jns.2018.10.025.
Jung N-Y, Han JC, Ong YT, Cheung CY-L, Chen CP, Wong TY, et al. Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease. J Neurol Sci. 2019 Jan 15;396:94–101.
Jung, Na-Yeon, et al. “Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.J Neurol Sci, vol. 396, Jan. 2019, pp. 94–101. Pubmed, doi:10.1016/j.jns.2018.10.025.
Jung N-Y, Han JC, Ong YT, Cheung CY-L, Chen CP, Wong TY, Kim HJ, Kim YJ, Lee J, Lee JS, Jang YK, Kee C, Lee KH, Kim E-J, Seo SW, Na DL. Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease. J Neurol Sci. 2019 Jan 15;396:94–101.
Journal cover image

Published In

J Neurol Sci

DOI

EISSN

1878-5883

Publication Date

January 15, 2019

Volume

396

Start / End Page

94 / 101

Location

Netherlands

Related Subject Headings

  • White Matter
  • Thiazoles
  • Risk Factors
  • Retina
  • Positron-Emission Tomography
  • Neuropsychological Tests
  • Middle Aged
  • Microvessels
  • Male
  • Magnetic Resonance Imaging