Immune response and insulin signalling alter mosquito feeding behaviour to enhance malaria transmission potential.

Published

Journal Article

Malaria parasites alter mosquito feeding behaviour in a way that enhances parasite transmission. This is widely considered a prime example of manipulation of host behaviour to increase onward transmission, but transient immune challenge in the absence of parasites can induce the same behavioural phenotype. Here, we show that alterations in feeding behaviour depend on the timing and dose of immune challenge relative to blood ingestion and that these changes are functionally linked to changes in insulin signalling in the mosquito gut. These results suggest that altered phenotypes derive from insulin signalling-dependent host resource allocation among immunity, blood feeding, and reproduction in a manner that is not specific to malaria parasite infection. We measured large increases in mosquito survival and subsequent transmission potential when feeding patterns are altered. Leveraging these changes in physiology, behaviour and life history could promote effective and sustainable control of female mosquitoes responsible for transmission.

Full Text

Cited Authors

  • Cator, LJ; Pietri, JE; Murdock, CC; Ohm, JR; Lewis, EE; Read, AF; Luckhart, S; Thomas, MB

Published Date

  • July 8, 2015

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 11947 -

PubMed ID

  • 26153094

Pubmed Central ID

  • 26153094

Electronic International Standard Serial Number (EISSN)

  • 2045-2322

International Standard Serial Number (ISSN)

  • 2045-2322

Digital Object Identifier (DOI)

  • 10.1038/srep11947

Language

  • eng