Malaria in India: the center for the study of complex malaria in India.

Published

Journal Article

Malaria is a major public health problem in India and one which contributes significantly to the overall malaria burden in Southeast Asia. The National Vector Borne Disease Control Program of India reported ∼1.6 million cases and ∼1100 malaria deaths in 2009. Some experts argue that this is a serious underestimation and that the actual number of malaria cases per year is likely between 9 and 50 times greater, with an approximate 13-fold underestimation of malaria-related mortality. The difficulty in making these estimations is further exacerbated by (i) highly variable malaria eco-epidemiological profiles, (ii) the transmission and overlap of multiple Plasmodium species and Anopheles vectors, (iii) increasing antimalarial drug resistance and insecticide resistance, and (iv) the impact of climate change on each of these variables. Simply stated, the burden of malaria in India is complex. Here we describe plans for a Center for the Study of Complex Malaria in India (CSCMi), one of ten International Centers of Excellence in Malaria Research (ICEMRs) located in malarious regions of the world recently funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health. The CSCMi is a close partnership between Indian and United States scientists, and aims to address major gaps in our understanding of the complexity of malaria in India, including changing patterns of epidemiology, vector biology and control, drug resistance, and parasite genomics. We hope that such a multidisciplinary approach that integrates clinical and field studies with laboratory, molecular, and genomic methods will provide a powerful combination for malaria control and prevention in India.

Full Text

Duke Authors

Cited Authors

  • Das, A; Anvikar, AR; Cator, LJ; Dhiman, RC; Eapen, A; Mishra, N; Nagpal, BN; Nanda, N; Raghavendra, K; Read, AF; Sharma, SK; Singh, OP; Singh, V; Sinnis, P; Srivastava, HC; Sullivan, SA; Sutton, PL; Thomas, MB; Carlton, JM; Valecha, N

Published Date

  • March 2012

Published In

Volume / Issue

  • 121 / 3

Start / End Page

  • 267 - 273

PubMed ID

  • 22142788

Pubmed Central ID

  • 22142788

Electronic International Standard Serial Number (EISSN)

  • 1873-6254

International Standard Serial Number (ISSN)

  • 0001-706X

Digital Object Identifier (DOI)

  • 10.1016/j.actatropica.2011.11.008

Language

  • eng