Microbiota of Inflammatory Bowel Disease Models.


Conference Paper

Gut microbiome plays an important role in inflammatory bowel disease (IBD), a group of intestinal chronic inflammation conditions that affect a large population. The animal models of IBD have long been established on basis of pathological features, but their ability to recapitulate patient gut microbiota is unknown. We investigated and compared the composition and biodiversity of bacterial population in the fecal samples from rat models of the two IBD subtypes, and compared them with patient samples. Our analyses revealed that inflammation reduces overall microbiome diversity and increased variation between individuals. We identified specific microbial signatures associated with the two IBD subtypes that were consistent between the animal models and human IBD patients, suggesting that the animal models can partially recapitulate the microbiota in human diseases. Furthermore, metagenome prediction analysis suggested microbial functions that were likely altered by host-microbiota interactions in IBD models.

Full Text

Duke Authors

Cited Authors

  • Gao, Z; Chen, K-Y; Mueller, O; Zhang, H; Rakhilin, N; Chen, J; Shen, X

Published Date

  • July 2018

Published In

Volume / Issue

  • 2018 /

Start / End Page

  • 2374 - 2377

PubMed ID

  • 30440884

Pubmed Central ID

  • 30440884

International Standard Serial Number (ISSN)

  • 1557-170X

Digital Object Identifier (DOI)

  • 10.1109/embc.2018.8512848