Delayed graft function in the kidney transplant.

Published

Journal Article (Review)

Acute kidney injury occurs with kidney transplantation and too frequently progresses to the clinical diagnosis of delayed graft function (DGF). Poor kidney function in the first week of graft life is detrimental to the longevity of the allograft. Challenges to understand the root cause of DGF include several pathologic contributors derived from the donor (ischemic injury, inflammatory signaling) and recipient (reperfusion injury, the innate immune response and the adaptive immune response). Progressive demand for renal allografts has generated new organ categories that continue to carry high risk for DGF for deceased donor organ transplantation. New therapies seek to subdue the inflammatory response in organs with high likelihood to benefit from intervention. Future success in suppressing the development of DGF will require a concerted effort to anticipate and treat tissue injury throughout the arc of the transplantation process.

Full Text

Duke Authors

Cited Authors

  • Siedlecki, A; Irish, W; Brennan, DC

Published Date

  • November 2011

Published In

Volume / Issue

  • 11 / 11

Start / End Page

  • 2279 - 2296

PubMed ID

  • 21929642

Pubmed Central ID

  • 21929642

Electronic International Standard Serial Number (EISSN)

  • 1600-6143

Digital Object Identifier (DOI)

  • 10.1111/j.1600-6143.2011.03754.x

Language

  • eng

Conference Location

  • United States