Clinical outcome of patients infected with hepatitis C virus infection on survival after primary liver transplantation under tacrolimus.

Journal Article (Journal Article)

The outcome of hepatitis C virus (HCV) infection on patient and graft survival after orthotopic liver transplantation (OLT) has been controversial. An earlier experience with a higher dose of tacrolimus (>/=0.1 mg/kg/d intravenously and >/=0.2 mg/kg/d orally) was associated with a worse clinical outcome in patients infected with HCV. The clinical outcome of 183 liver transplant recipients with end-stage liver disease (ESLD) secondary to HCV infection (HCV group) was compared with a contemporary cohort of 556 patients with HCV infection who underwent transplantation for nonviral, nonmalignant ESLD (control group). All patients were prospectively screened for anti-HCV antibodies and HCV RNA by reverse-transcriptase polymerase chain reaction. All OLT patients were receiving low-dose tacrolimus immunosuppression. Cumulative patient survival rates for the HCV group were 80% after 1 year and 75% after 3 years compared with rates of 84% and 78%, respectively, in the control group (P = .452). Primary graft survival rates at the same time intervals for the HCV group and the control group were 72% and 77.5% at 1 year and 67% and 72% at 3 years, respectively (P = .144). The incidence of re-transplantation (re-OLT) in the HCV group and the control group was 12.6% and 10.4%, respectively (P = .42). Chronic HCV infection as an indication for OLT with a lower dose of tacrolimus immunosuppression (

Full Text

Duke Authors

Cited Authors

  • Casavilla, FA; Rakela, J; Kapur, S; Irish, W; McMichael, J; Demetris, AJ; Starzl, TE; Fung, JJ

Published Date

  • November 1998

Published In

Volume / Issue

  • 4 / 6

Start / End Page

  • 448 - 454

PubMed ID

  • 9791154

Pubmed Central ID

  • 9791154

International Standard Serial Number (ISSN)

  • 1074-3022

Digital Object Identifier (DOI)

  • 10.1002/lt.500040605


  • eng

Conference Location

  • United States