Cytomegalovirus infection after intestinal transplantation in children.
Published
Journal Article
Sixteen episodes of cytomegalovirus (CMV) disease occurred in 10 of 41 children undergoing intestinal transplantation from 1990 to 1995. Stratification of CMV disease by donor (D)/recipient (R) serological status was as follows: 3 of 8, D+/R-; 3 of 9, D+/R+; 4 of 9, D-/R+; and 0 of 15, D-/R-. Treatment resulted in resolution of CMV disease in 93.3% of episodes. No deaths attributable to CMV disease occurred in this series. CMV in D+/R- children resulted in more extensive and persistent disease. However, patient and graft survival rates were similar in the different D/R subgroups and between children with and without CMV disease. Cumulative dose of steroid boluses (relative risk [RR], 1.59; 95% confidence interval [CI], 1.14-2.21) and history of steroid recycles (RR, 2.72; 95% CI, 1.21-6.13) were associated with CMV disease. These results suggest that although CMV-associated morbidity in pediatric intestinal transplant recipients was substantial, it was not associated with an increased rate of mortality or graft loss, even among high-risk D+/R- patients.
Full Text
Duke Authors
Cited Authors
- Bueno, J; Green, M; Kocoshis, S; Furukawa, H; Abu-Elmagd, K; Yunis, E; Irish, W; Todo, S; Reyes, J; Starzl, TE
Published Date
- November 1997
Published In
- Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Volume / Issue
- 25 / 5
Start / End Page
- 1078 - 1083
PubMed ID
- 9402361
Pubmed Central ID
- 9402361
International Standard Serial Number (ISSN)
- 1058-4838
Digital Object Identifier (DOI)
- 10.1086/516113
Language
- eng
Conference Location
- United States