Cytomegalovirus infection after intestinal transplantation in children.

Published

Journal Article

Sixteen episodes of cytomegalovirus (CMV) disease occurred in 10 of 41 children undergoing intestinal transplantation from 1990 to 1995. Stratification of CMV disease by donor (D)/recipient (R) serological status was as follows: 3 of 8, D+/R-; 3 of 9, D+/R+; 4 of 9, D-/R+; and 0 of 15, D-/R-. Treatment resulted in resolution of CMV disease in 93.3% of episodes. No deaths attributable to CMV disease occurred in this series. CMV in D+/R- children resulted in more extensive and persistent disease. However, patient and graft survival rates were similar in the different D/R subgroups and between children with and without CMV disease. Cumulative dose of steroid boluses (relative risk [RR], 1.59; 95% confidence interval [CI], 1.14-2.21) and history of steroid recycles (RR, 2.72; 95% CI, 1.21-6.13) were associated with CMV disease. These results suggest that although CMV-associated morbidity in pediatric intestinal transplant recipients was substantial, it was not associated with an increased rate of mortality or graft loss, even among high-risk D+/R- patients.

Full Text

Duke Authors

Cited Authors

  • Bueno, J; Green, M; Kocoshis, S; Furukawa, H; Abu-Elmagd, K; Yunis, E; Irish, W; Todo, S; Reyes, J; Starzl, TE

Published Date

  • November 1997

Published In

Volume / Issue

  • 25 / 5

Start / End Page

  • 1078 - 1083

PubMed ID

  • 9402361

Pubmed Central ID

  • 9402361

International Standard Serial Number (ISSN)

  • 1058-4838

Digital Object Identifier (DOI)

  • 10.1086/516113

Language

  • eng

Conference Location

  • United States