A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.

Journal Article (Journal Article)

Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity results from competing charge transfer to the protein and through the DNA, with implications on the use of genome editing tools to influence the p53 regulatory function.

Full Text

Duke Authors

Beratan, David N.

Cited Authors

Teo, RD; Smithwick, ER; Migliore, A; Beratan, DN

Published Date

December 2018

Published In

Chemical Communications

Volume / Issue

55 / 2

Start / End Page

206 - 209

PubMed ID

30520908

Pubmed Central ID

PMC6314182

Electronic International Standard Serial Number (EISSN)

1364-548X

International Standard Serial Number (ISSN)

1359-7345

Digital Object Identifier (DOI)

10.1039/c8cc09048c

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