A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.
Publication
, Journal Article
Teo, RD; Smithwick, ER; Migliore, A; Beratan, DN
Published in: Chemical communications (Cambridge, England)
December 2018
Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity results from competing charge transfer to the protein and through the DNA, with implications on the use of genome editing tools to influence the p53 regulatory function.
Duke Scholars
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Published In
Chemical communications (Cambridge, England)
DOI
EISSN
1364-548X
ISSN
1359-7345
Publication Date
December 2018
Volume
55
Issue
2
Start / End Page
206 / 209
Related Subject Headings
- Tumor Suppressor Protein p53
- Static Electricity
- Protein Binding
- Organic Chemistry
- Molecular Dynamics Simulation
- DNA
- Consensus Sequence
- Base Pairing
- 40 Engineering
- 34 Chemical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Teo, R. D., Smithwick, E. R., Migliore, A., & Beratan, D. N. (2018). A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation. Chemical Communications (Cambridge, England), 55(2), 206–209. https://doi.org/10.1039/c8cc09048c
Teo, Ruijie D., Elizabeth R. Smithwick, Agostino Migliore, and David N. Beratan. “A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.” Chemical Communications (Cambridge, England) 55, no. 2 (December 2018): 206–9. https://doi.org/10.1039/c8cc09048c.
Teo RD, Smithwick ER, Migliore A, Beratan DN. A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation. Chemical communications (Cambridge, England). 2018 Dec;55(2):206–9.
Teo, Ruijie D., et al. “A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.” Chemical Communications (Cambridge, England), vol. 55, no. 2, Dec. 2018, pp. 206–09. Epmc, doi:10.1039/c8cc09048c.
Teo RD, Smithwick ER, Migliore A, Beratan DN. A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation. Chemical communications (Cambridge, England). 2018 Dec;55(2):206–209.
Published In
Chemical communications (Cambridge, England)
DOI
EISSN
1364-548X
ISSN
1359-7345
Publication Date
December 2018
Volume
55
Issue
2
Start / End Page
206 / 209
Related Subject Headings
- Tumor Suppressor Protein p53
- Static Electricity
- Protein Binding
- Organic Chemistry
- Molecular Dynamics Simulation
- DNA
- Consensus Sequence
- Base Pairing
- 40 Engineering
- 34 Chemical sciences