A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.
Journal Article (Journal Article)
Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity results from competing charge transfer to the protein and through the DNA, with implications on the use of genome editing tools to influence the p53 regulatory function.
Full Text
Duke Authors
Cited Authors
- Teo, RD; Smithwick, ER; Migliore, A; Beratan, DN
Published Date
- December 2018
Published In
Volume / Issue
- 55 / 2
Start / End Page
- 206 - 209
PubMed ID
- 30520908
Pubmed Central ID
- PMC6314182
Electronic International Standard Serial Number (EISSN)
- 1364-548X
International Standard Serial Number (ISSN)
- 1359-7345
Digital Object Identifier (DOI)
- 10.1039/c8cc09048c
Language
- eng