A single AT-GC exchange can modulate charge transfer-induced p53-DNA dissociation.

Journal Article (Journal Article)

Using molecular dynamics simulations and electronic structure theory, we shed light on the charge dynamics that causes the differential interaction of tumor suppressor protein p53 with the p21 and Gadd45 genes in response to oxidative stress. We show that the sequence dependence of this selectivity results from competing charge transfer to the protein and through the DNA, with implications on the use of genome editing tools to influence the p53 regulatory function.

Full Text

Duke Authors

Cited Authors

  • Teo, RD; Smithwick, ER; Migliore, A; Beratan, DN

Published Date

  • December 2018

Published In

Volume / Issue

  • 55 / 2

Start / End Page

  • 206 - 209

PubMed ID

  • 30520908

Pubmed Central ID

  • PMC6314182

Electronic International Standard Serial Number (EISSN)

  • 1364-548X

International Standard Serial Number (ISSN)

  • 1359-7345

Digital Object Identifier (DOI)

  • 10.1039/c8cc09048c


  • eng