Short course induction immunosuppression with thymoglobulin for renal transplant recipients.


Journal Article

BACKGROUND: The aim of this study was to demonstrate that 3-days of induction immunosuppression with thymoglobulin was as effective and safe as a 7-day course and reduced initial hospitalization after transplantation. METHODS: This was a prospective, nonrandomized trial of 40 consecutive patients receiving thymoglobulin induction for 3 days and followed for 1 year. An historical group of 48 patients that received 7 days of thymoglobulin served as controls. RESULTS: At 1 year, acute rejection (5 vs. 4%), graft survival (95 vs. 98%) and patient survival were similar; a composite end point of freedom from death, rejection, or graft loss, the event-free graft survival, was similar as was the safety profile. In the 3-day group, lymphocyte depletion was more sustained and initial hospitalization was significantly shorter (6 vs. 8 days). CONCLUSION: Three-day induction with thymoglobulin is as effective and safe as seven days, decreases initial hospitalization and causes more sustained lymphocyte depletion.

Full Text

Duke Authors

Cited Authors

  • Agha, IA; Rueda, J; Alvarez, A; Singer, GG; Miller, BW; Flavin, K; Lowell, JA; Shenoy, S; Howard, TK; Ramachandran, V; Irish, W; Schnitzle, MA; Brennan, DC

Published Date

  • February 15, 2002

Published In

Volume / Issue

  • 73 / 3

Start / End Page

  • 473 - 475

PubMed ID

  • 11884948

Pubmed Central ID

  • 11884948

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-200202150-00025


  • eng

Conference Location

  • United States