Can adenine nucleotides predict primary nonfunction of the human liver homograft?

Journal Article (Journal Article)

Sixty-eight primary liver grafts were analyzed to see whether adenine nucleotides (AN: ATP, ADP, and AMP) or purine catabolites (PC: adenosine, inosine, hypoxanthine, and xanthine) of tissue or effluent can predict primary graft nonfunction. AN, PC, and nicotinamide adenine dinucleotide, oxidized form (NAD+) of the tissue before (pretransplant) and after graft reperfusion (post-transplant) and of the effluent were analyzed. The graft outcome was classified into two groups (group A: successful, n = 64; group B: primary nonfunctioning, n = 4). No significant differences were observed in pretransplant measurements between groups A and B, whereas ATP, ADP, total AN, total AN + total PC (T) and NAD+, in post-transplant tissues, were significantly higher in group A. Xanthine in the effluent was significantly higher in group B than in group A. ATP, ADP, total AN, T, and NAD+ in post-transplant tissue were significantly associated with primary graft nonfunction by logistic regression analysis.

Full Text

Duke Authors

Cited Authors

  • Hamamoto, I; Takaya, S; Todo, S; Bronsther, O; Fujita, S; Van Gulik, TM; Nakamura, K; Irish, W; Starzl, TE

Published Date

  • 1994

Published In

Volume / Issue

  • 7 / 2

Start / End Page

  • 89 - 95

PubMed ID

  • 8179809

Pubmed Central ID

  • 8179809

International Standard Serial Number (ISSN)

  • 0934-0874

Digital Object Identifier (DOI)

  • 10.1007/BF00336468


  • eng

Conference Location

  • England