Endothelial Contributions to Zebrafish Heart Regeneration.

Journal Article (Journal Article;Review)

Studies over the past two decades have shown heart regeneration in zebrafish to be a dynamic process, choreographed by multiple cell types. In particular, recent work has identified revascularization of the wound to be a sentinel event during heart regeneration. The cardiac endothelium has emerged as a key orchestrator of heart regeneration, influencing cardiomyocyte hyperplasia and tissue morphogenesis. Here, we review how the coronary vasculature regenerates after injury, how signaling pathways link the cardiac endothelium to heart regeneration, and how understanding these signaling dynamics can lead to targeted therapies for heart regeneration.

Full Text

Duke Authors

Cited Authors

  • Fernandez, CE; Bakovic, M; Karra, R

Published Date

  • December 11, 2018

Published In

Volume / Issue

  • 5 / 4

PubMed ID

  • 30544906

Pubmed Central ID

  • PMC6306804

Electronic International Standard Serial Number (EISSN)

  • 2308-3425

Digital Object Identifier (DOI)

  • 10.3390/jcdd5040056


  • eng

Conference Location

  • Switzerland