Maternal immunisation to improve the health of HIV-exposed infants.

Journal Article (Journal Article;Review)

HIV-exposed but uninfected (HEU) infants are at an increased risk of many infectious diseases that can contribute to the high mortality seen among HEU children. Maternal immunisation could be a promising strategy to reduce infections in HEU infants. However, very little research has explored the effect of HIV on the immunogenicity and effectiveness of vaccines given during pregnancy. We review the available evidence on maternal immunisation among women living with HIV (WLWH) for all vaccines recommended, considered, or being investigated for routine or risk-based use during pregnancy. Of the 11 vaccines included, only three have been investigated in WLWH. Available evidence suggests that maternal HIV infection limits the immunogenicity of several vaccines, leaving HEU infants more susceptible to infection during their first few months of life. Whether maternal immunisation reduces the infectious morbidity and mortality associated with infectious diseases in HEU children remains unknown. We conclude the Review by identifying future research priorities.

Full Text

Duke Authors

Cited Authors

  • Bengtson, AM; Sanfilippo, AM; Hughes, BL; Savitz, DA

Published Date

  • April 2019

Published In

Volume / Issue

  • 19 / 4

Start / End Page

  • e120 - e131

PubMed ID

  • 30529212

Pubmed Central ID

  • PMC6891820

Electronic International Standard Serial Number (EISSN)

  • 1474-4457

Digital Object Identifier (DOI)

  • 10.1016/S1473-3099(18)30545-0


  • eng

Conference Location

  • United States