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Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation.

Publication ,  Journal Article
Ustun, C; Young, J-AH; Papanicolaou, GA; Kim, S; Ahn, KW; Chen, M; Abdel-Azim, H; Aljurf, M; Beitinjaneh, A; Brown, V; Cerny, J; Chhabra, S ...
Published in: Bone marrow transplantation
August 2019

We analyzed CIBMTR data to evaluate the incidence of non-relapse mortality (NRM) and association with overall survival (OS) for bacterial blood stream infections (BSIs) occurring within 100 days of alloHCT in 2 different phases: pre-/peri-engraftment (BSI very early phase, BSI-VEP) and BSI post-engraftment (BSI occurring between 2 weeks after engraftment and day 100, late early phase, BSI-LEP). Of the 7128 alloHCT patients, 2656 (37%) had ≥1 BSI by day 100. BSI-VEP, BSI-LEP, and BSI-Both constituted 56% (n = 1492), 31% (n = 824), and 13% (n = 340) of total BSI, respectively. Starting in 2009, we observed a gradual decline in BSI incidence through 2012 (61-48%). Patients with BSI-VEP were more likely to receive a myeloablative conditioning (MAC) regimen with total body irradiation (TBI). NRM was significantly higher in patients with any BSI (RR 1.82 95% CI 1.63-2.04 for BSI-VEP, RR 2.46, 95% CI 2.05-2.96 for BSI-LEP, and RR 2.29, 95% CI 1.87-2.81 for BSI-Both) compared with those without BSI. OS was significantly lower in patients with any BSI compared with patients without BSI (RR 1.36, 95% CI 1.26-1.47 for BSI-VEP; RR 1.83, 95% CI 1.58-2.12 for BSI-LEP: RR 1.66, 95% CI 1.43-1.94 for BSI-Both). BSIs within day 100 after alloHCT are common and remain a risk factor for mortality.

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Published In

Bone marrow transplantation

DOI

EISSN

1476-5365

ISSN

0268-3369

Publication Date

August 2019

Volume

54

Issue

8

Start / End Page

1254 / 1265

Related Subject Headings

  • Young Adult
  • Transplantation, Homologous
  • Transplantation Conditioning
  • Risk Factors
  • Mortality
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation
 

Citation

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Chicago
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Ustun, C., Young, J.-A., Papanicolaou, G. A., Kim, S., Ahn, K. W., Chen, M., … Riches, M. (2019). Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation. Bone Marrow Transplantation, 54(8), 1254–1265. https://doi.org/10.1038/s41409-018-0401-4
Ustun, Celalettin, Jo-Anne H. Young, Genovefa A. Papanicolaou, Soyoung Kim, Kwang Woo Ahn, Min Chen, Hisham Abdel-Azim, et al. “Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation.Bone Marrow Transplantation 54, no. 8 (August 2019): 1254–65. https://doi.org/10.1038/s41409-018-0401-4.
Ustun C, Young J-AH, Papanicolaou GA, Kim S, Ahn KW, Chen M, et al. Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation. Bone marrow transplantation. 2019 Aug;54(8):1254–65.
Ustun, Celalettin, et al. “Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation.Bone Marrow Transplantation, vol. 54, no. 8, Aug. 2019, pp. 1254–65. Epmc, doi:10.1038/s41409-018-0401-4.
Ustun C, Young J-AH, Papanicolaou GA, Kim S, Ahn KW, Chen M, Abdel-Azim H, Aljurf M, Beitinjaneh A, Brown V, Cerny J, Chhabra S, Kharfan-Dabaja MA, Dahi PB, Daly A, Dandoy CE, Dvorak CC, Freytes CO, Hashmi S, Lazarus H, Ljungman P, Nishihori T, Page K, Pingali SRK, Saad A, Savani BN, Weisdorf D, Williams K, Wirk B, Auletta JJ, Lindemans CA, Komanduri K, Riches M. Bacterial blood stream infections (BSIs), particularly post-engraftment BSIs, are associated with increased mortality after allogeneic hematopoietic cell transplantation. Bone marrow transplantation. 2019 Aug;54(8):1254–1265.

Published In

Bone marrow transplantation

DOI

EISSN

1476-5365

ISSN

0268-3369

Publication Date

August 2019

Volume

54

Issue

8

Start / End Page

1254 / 1265

Related Subject Headings

  • Young Adult
  • Transplantation, Homologous
  • Transplantation Conditioning
  • Risk Factors
  • Mortality
  • Middle Aged
  • Male
  • Immunology
  • Humans
  • Hematopoietic Stem Cell Transplantation