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Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study.

Publication ,  Journal Article
Geng, T-T; Jafar, TH; Yuan, J-M; Koh, W-P
Published in: Sleep medicine
February 2019

Although epidemiological evidence suggests that short sleep duration may affect renal function, the influence of long sleep and risk of end-stage renal disease (ESRD) is unclear. We examined the association between sleep duration and risk of ESRD.We investigated sleep duration and ESRD risk in the Singapore Chinese Health Study, a prospective population-based cohort of 63,257 Chinese in Singapore, who were aged 45-74 years at recruitment (1993-1998). Information on daily sleep duration (including naps), diet, medical history and other lifestyle factors was collected at recruitment from in-person interviews. ESRD cases were identified via linkage with the nationwide Singapore Renal Registry through year 2014. We used the Cox proportional hazards regression method to estimate hazard ratio (HR) and 95% confidence interval (CI) of ESRD in relation to sleep duration.After an average 16.8 years of follow-up, 1143 (1.81%) ESRD cases were documented. Sleep duration had a U-shaped association with risk of ESRD (P for quadratic trend < 0.001). Compared with participants with 7 h/day of sleep, the multivariable adjusted HR (95% CI) of ESRD was 1.43 (1.18-1.74) for short sleep (≤5 h/day) and 1.28 (1.03-1.60) for long sleep duration (≥9 h/day). The increased risk was stronger in participants with more than 10 years of follow-up compared to those with shorter follow-up time, especially for long sleep (P for interaction = 0.003).Our findings demonstrated that both short and long sleep durations were associated with a higher risk of ESRD in this Asian population.

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Published In

Sleep medicine

DOI

EISSN

1878-5506

ISSN

1389-9457

Publication Date

February 2019

Volume

54

Start / End Page

22 / 27

Related Subject Headings

  • Time Factors
  • Sleep
  • Singapore
  • Risk Factors
  • Registries
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Life Style
 

Citation

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Geng, T.-T., Jafar, T. H., Yuan, J.-M., & Koh, W.-P. (2019). Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study. Sleep Medicine, 54, 22–27. https://doi.org/10.1016/j.sleep.2018.10.007
Geng, Ting-Ting, Tazeen Hasan Jafar, Jian-Min Yuan, and Woon-Puay Koh. “Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study.Sleep Medicine 54 (February 2019): 22–27. https://doi.org/10.1016/j.sleep.2018.10.007.
Geng T-T, Jafar TH, Yuan J-M, Koh W-P. Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study. Sleep medicine. 2019 Feb;54:22–7.
Geng, Ting-Ting, et al. “Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study.Sleep Medicine, vol. 54, Feb. 2019, pp. 22–27. Epmc, doi:10.1016/j.sleep.2018.10.007.
Geng T-T, Jafar TH, Yuan J-M, Koh W-P. Sleep duration and risk of end-stage renal disease: the Singapore Chinese Health Study. Sleep medicine. 2019 Feb;54:22–27.
Journal cover image

Published In

Sleep medicine

DOI

EISSN

1878-5506

ISSN

1389-9457

Publication Date

February 2019

Volume

54

Start / End Page

22 / 27

Related Subject Headings

  • Time Factors
  • Sleep
  • Singapore
  • Risk Factors
  • Registries
  • Prospective Studies
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Life Style