JCL roundtable-Lipoprotein(a): The emerging risk factor.

Journal Article (Journal Article)

Lipoprotein(a), or Lp(a), is a major risk factor for atherothrombotic events along with low-density lipoprotein cholesterol and, inversely, high-density lipoprotein cholesterol. Lp(a) also contributes to the progression of calcific aortic stenosis and to the rare occurrence of arterial thrombotic strokes without atherosclerosis in children and younger women. Much has been learned about the inheritance of Lp(a) levels and the relationship between apolipoprotein(a) structure and function. Recent work suggests an intriguing interaction between oxidized phospholipids on Lp(a) and inflammatory interleukin-1 genotypes. New pharmaceutical approaches with antisense and RNA interference technology may achieve up to 90% lowering of Lp(a). This Roundtable includes practical considerations for clinically measuring and responding to Lp(a) levels.

Full Text

Duke Authors

Cited Authors

  • Marcovina, SM; Moriarty, PM; Koschinsky, ML; Guyton, JR

Published Date

  • November 2018

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 1335 - 1345

PubMed ID

  • 30527801

International Standard Serial Number (ISSN)

  • 1933-2874

Digital Object Identifier (DOI)

  • 10.1016/j.jacl.2018.11.003

Language

  • eng

Conference Location

  • United States