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JCL roundtable-Lipoprotein(a): The emerging risk factor.

Publication ,  Journal Article
Marcovina, SM; Moriarty, PM; Koschinsky, ML; Guyton, JR
Published in: J Clin Lipidol
2018

Lipoprotein(a), or Lp(a), is a major risk factor for atherothrombotic events along with low-density lipoprotein cholesterol and, inversely, high-density lipoprotein cholesterol. Lp(a) also contributes to the progression of calcific aortic stenosis and to the rare occurrence of arterial thrombotic strokes without atherosclerosis in children and younger women. Much has been learned about the inheritance of Lp(a) levels and the relationship between apolipoprotein(a) structure and function. Recent work suggests an intriguing interaction between oxidized phospholipids on Lp(a) and inflammatory interleukin-1 genotypes. New pharmaceutical approaches with antisense and RNA interference technology may achieve up to 90% lowering of Lp(a). This Roundtable includes practical considerations for clinically measuring and responding to Lp(a) levels.

Duke Scholars

Published In

J Clin Lipidol

DOI

ISSN

1933-2874

Publication Date

2018

Volume

12

Issue

6

Start / End Page

1335 / 1345

Location

United States

Related Subject Headings

  • Risk Factors
  • Lipoprotein(a)
  • Humans
  • Cardiovascular System & Hematology
  • Atherosclerosis
  • 3205 Medical biochemistry and metabolomics
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
  • 1101 Medical Biochemistry and Metabolomics
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Marcovina, S. M., Moriarty, P. M., Koschinsky, M. L., & Guyton, J. R. (2018). JCL roundtable-Lipoprotein(a): The emerging risk factor. J Clin Lipidol, 12(6), 1335–1345. https://doi.org/10.1016/j.jacl.2018.11.003
Marcovina, Santica M., Patrick M. Moriarty, Marlys L. Koschinsky, and John R. Guyton. “JCL roundtable-Lipoprotein(a): The emerging risk factor.J Clin Lipidol 12, no. 6 (2018): 1335–45. https://doi.org/10.1016/j.jacl.2018.11.003.
Marcovina SM, Moriarty PM, Koschinsky ML, Guyton JR. JCL roundtable-Lipoprotein(a): The emerging risk factor. J Clin Lipidol. 2018;12(6):1335–45.
Marcovina, Santica M., et al. “JCL roundtable-Lipoprotein(a): The emerging risk factor.J Clin Lipidol, vol. 12, no. 6, 2018, pp. 1335–45. Pubmed, doi:10.1016/j.jacl.2018.11.003.
Marcovina SM, Moriarty PM, Koschinsky ML, Guyton JR. JCL roundtable-Lipoprotein(a): The emerging risk factor. J Clin Lipidol. 2018;12(6):1335–1345.
Journal cover image

Published In

J Clin Lipidol

DOI

ISSN

1933-2874

Publication Date

2018

Volume

12

Issue

6

Start / End Page

1335 / 1345

Location

United States

Related Subject Headings

  • Risk Factors
  • Lipoprotein(a)
  • Humans
  • Cardiovascular System & Hematology
  • Atherosclerosis
  • 3205 Medical biochemistry and metabolomics
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
  • 1101 Medical Biochemistry and Metabolomics