Genetic variants associated with patent ductus arteriosus in extremely preterm infants.

Journal Article (Journal Article)

OBJECTIVE: Patent ductus arteriosus (PDA) is a commonly observed condition in preterm infants. Prior studies have suggested a role for genetics in determining spontaneous ductal closure. Using samples from a large neonatal cohort we tested the hypothesis that common genetic variations are associated with PDA in extremely preterm infants. STUDY DESIGN: Preterm infants (n = 1013) enrolled at NICHD Neonatal Research Network sites were phenotyped for PDA. DNA was genotyped for 1634 single nucleotide polymorphisms (SNPs) from candidate genes. Analyses were adjusted for ancestral eigenvalues and significant epidemiologic variables. RESULTS: SNPs in several genes were associated with the clinical diagnosis of PDA and with surgical ligation in extremely preterm neonates diagnosed with PDA (p < 0.01). None of the associations were significant after correction for multiple comparisons. CONCLUSION: We identified several common genetic variants associated with PDA. These findings may inform further studies on genetic risk factors for PDA in preterm infants.

Full Text

Duke Authors

Cited Authors

  • Dagle, JM; Ryckman, KK; Spracklen, CN; Momany, AM; Cotten, CM; Levy, J; Page, GP; Bell, EF; Carlo, WA; Shankaran, S; Goldberg, RN; Ehrenkranz, RA; Tyson, JE; Stoll, BJ; Murray, JC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network,

Published Date

  • March 2019

Published In

Volume / Issue

  • 39 / 3

Start / End Page

  • 401 - 408

PubMed ID

  • 30518802

Pubmed Central ID

  • PMC6391165

Electronic International Standard Serial Number (EISSN)

  • 1476-5543

Digital Object Identifier (DOI)

  • 10.1038/s41372-018-0285-6


  • eng

Conference Location

  • United States