Lysosomal storage and transport disorders

Published

Book Section

© 2008 by Informa Healthcare USA, Inc. Lysosomes were discovered in 1959 through a series of brilliant investigations by de Duve and coworkers (14,15). These cytoplasmic organelles, ubiquitous in distribution in living cells, show great diversity in form, origin, and function. Varying in diameter from approximately 0.25 to 0.5 mm, they are easily recognizable by their characteristic biochemical and morphological properties. Lysosomes are a component of a system of intracellular organelles known as the endosomal-lysosomal system (16). This system consists of three parts: the early endosome, the late endosome and the lysosome (primary and secondary) which together are responsible for trafficking and digestion of endocytosed molecules and also for recycling and sorting of materials within the cellular matrix (51). Lysosomes are the sole site of digestive activity in living cells.

Duke Authors

Cited Authors

  • Demo, E; Koeberl, DD; Kishnani, PS

Published Date

  • January 1, 2007

Book Title

  • Garner and Klintworth's Pathobiology of Ocular Disease Part B, Third Edition

Start / End Page

  • 857 - 868

International Standard Book Number 10 (ISBN-10)

  • 142007976X

International Standard Book Number 13 (ISBN-13)

  • 9781420079760

Citation Source

  • Scopus