TET2 Deficiency Sets the Stage for B-cell Lymphoma.

Journal Article (Journal Article)

TET2 is a well-established tumor suppressor in the context of myeloid malignancies, but its role in lymphoma development has been less clear. In this issue of Cancer Discovery, Dominguez and colleagues report that TET2 function is critical for germinal center exit and plasma cell differentiation, and its deficiency can lead to B-cell lymphoma phenotypes.See related article by Dominguez et al., p. 1632.

Full Text

Duke Authors

Cited Authors

  • Shingleton, JR; Dave, SS

Published Date

  • December 2018

Published In

Volume / Issue

  • 8 / 12

Start / End Page

  • 1515 - 1517

PubMed ID

  • 30510015

Electronic International Standard Serial Number (EISSN)

  • 2159-8290

Digital Object Identifier (DOI)

  • 10.1158/2159-8290.CD-18-1143

Language

  • eng

Conference Location

  • United States