Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.

Journal Article (Clinical Trial;Journal Article)

Unlike other nonsteroidal antiinflammatory agents, benoxaprofen has only minor antiprostaglandin synthetase activity. This property may explain the lack of gastric irritation seen in animal studies. To evaluate gastric irritation in man, benoxaprofen was compared with aspirin, naproxen, ibuprofen, sulindac, and indomethacin by measuring fecal blood loss with chromium-51 tagged red blood cells in randomized double-blind crossover and parallel studies. Benoxaprofen produced significantly less blood loss than aspirin, naproxen, or indomethacin, and less blood loss than ibuprofen or sulindac. Benoxaprofen also caused the fewest gastrointestinal complaints.

Full Text

Duke Authors

Cited Authors

  • Ridolfo, AS; Crabtree, RE; Johnson, DW; Rockhold, FW

Published Date

  • 1980

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 36 - 47

PubMed ID

  • 6993671

International Standard Serial Number (ISSN)

  • 0380-0903


  • eng

Conference Location

  • Canada