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Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.

Publication ,  Journal Article
Ridolfo, AS; Crabtree, RE; Johnson, DW; Rockhold, FW
Published in: J Rheumatol Suppl
1980

Unlike other nonsteroidal antiinflammatory agents, benoxaprofen has only minor antiprostaglandin synthetase activity. This property may explain the lack of gastric irritation seen in animal studies. To evaluate gastric irritation in man, benoxaprofen was compared with aspirin, naproxen, ibuprofen, sulindac, and indomethacin by measuring fecal blood loss with chromium-51 tagged red blood cells in randomized double-blind crossover and parallel studies. Benoxaprofen produced significantly less blood loss than aspirin, naproxen, or indomethacin, and less blood loss than ibuprofen or sulindac. Benoxaprofen also caused the fewest gastrointestinal complaints.

Duke Scholars

Published In

J Rheumatol Suppl

ISSN

0380-0903

Publication Date

1980

Volume

6

Start / End Page

36 / 47

Location

Canada

Related Subject Headings

  • Time Factors
  • Sulindac
  • Prostaglandins
  • Propionates
  • Naproxen
  • Melena
  • Indomethacin
  • Humans
  • Gastrointestinal Hemorrhage
  • Double-Blind Method
 

Citation

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Ridolfo, A. S., Crabtree, R. E., Johnson, D. W., & Rockhold, F. W. (1980). Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents. J Rheumatol Suppl, 6, 36–47.
Ridolfo, A. S., R. E. Crabtree, D. W. Johnson, and F. W. Rockhold. “Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.J Rheumatol Suppl 6 (1980): 36–47.
Ridolfo AS, Crabtree RE, Johnson DW, Rockhold FW. Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents. J Rheumatol Suppl. 1980;6:36–47.
Ridolfo, A. S., et al. “Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents.J Rheumatol Suppl, vol. 6, 1980, pp. 36–47.
Ridolfo AS, Crabtree RE, Johnson DW, Rockhold FW. Gastrointestinal microbleeding: comparisons between benoxaprofen and other nonsteroidal antiinflammatory agents. J Rheumatol Suppl. 1980;6:36–47.

Published In

J Rheumatol Suppl

ISSN

0380-0903

Publication Date

1980

Volume

6

Start / End Page

36 / 47

Location

Canada

Related Subject Headings

  • Time Factors
  • Sulindac
  • Prostaglandins
  • Propionates
  • Naproxen
  • Melena
  • Indomethacin
  • Humans
  • Gastrointestinal Hemorrhage
  • Double-Blind Method