DNA methylation and obesity in survivors of pediatric acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study.

Published

Journal Article

Because survivors of pediatric acute lymphoblastic leukemia (ALL) are more likely to be obese than unaffected contemporaries, we compared DNA methylation profiles between normal-weight and obese survivors at adiposity-associated CpG sites previously-reported by epigenome-wide association studies (EWAS) of body mass index (BMI) in the general population. We selected 96 ALL survivors from the Childhood Cancer Survivor Study: 48 obese and 48 normal weight. The Illumina HumanMethylation450 BeadChip was used to compare DNA methylation at 211 loci identified in EWAS of BMI in the general population. Thirty-nine loci were associated (false discovery rate <0.05) with obesity among survivors who only received chemotherapy (n = 49). No loci were significantly associated with obesity among CRT-exposed survivors (n = 47). Our results suggest that previously identified BMI-DNA methylation loci are associated with obesity in ALL survivors who were spared CRT, while no loci were significantly associated with obesity in survivors who received CRT.

Full Text

Duke Authors

Cited Authors

  • Lupo, PJ; Brown, AL; Arroyo, VM; Kamdar, KY; Belmont, JW; Scheurer, ME; Leisenring, WM; Gramatges, MM; Okcu, MF; Yasui, Y; Oeffinger, KC; Robison, LL; Armstrong, GT; Bhatia, S

Published Date

  • January 2019

Published In

Volume / Issue

  • 58 / 1

Start / End Page

  • 52 - 59

PubMed ID

  • 30382603

Pubmed Central ID

  • 30382603

Electronic International Standard Serial Number (EISSN)

  • 1098-2264

International Standard Serial Number (ISSN)

  • 1045-2257

Digital Object Identifier (DOI)

  • 10.1002/gcc.22701

Language

  • eng