The Assembling and Contraction Mechanisms of Striated Muscles.

Published

Journal Article

A novel approach to the description of the assembly mechanism of functional biological structures is presented. The approach is based on the identification of fundamental self-assembling processes to which an additional structurization "engineered" by Nature to optimize functions is superimposed. Application of the approach to the structure and contraction of the striated muscle evidences a key role of the residual liquid crystallinity of a constrained structure and the alteration of the compatibility between the thin and thick filaments driven by ionic interactions. ATP hydrolysis boosts the relaxation process. A strong protein scaffold, engineered during the evolutionary process and based on the selective anchoring of coordinated filaments, directs a demixing tendency of the two filaments toward a sliding motion along the fiber axis. The Huxley-Hanson sliding filament hypothesis aimed to explain the contraction-relaxation function of the striated muscle, but does not offer any clue on the overall assembling mechanism of the myofibril.

Full Text

Duke Authors

Cited Authors

  • Ciferri, A; Crumbliss, AL

Published Date

  • January 2018

Published In

Volume / Issue

  • 6 /

Start / End Page

  • 570 -

PubMed ID

  • 30555818

Pubmed Central ID

  • 30555818

Electronic International Standard Serial Number (EISSN)

  • 2296-2646

International Standard Serial Number (ISSN)

  • 2296-2646

Digital Object Identifier (DOI)

  • 10.3389/fchem.2018.00570

Language

  • eng