The Assembling and Contraction Mechanisms of Striated Muscles.
Journal Article (Journal Article)
A novel approach to the description of the assembly mechanism of functional biological structures is presented. The approach is based on the identification of fundamental self-assembling processes to which an additional structurization "engineered" by Nature to optimize functions is superimposed. Application of the approach to the structure and contraction of the striated muscle evidences a key role of the residual liquid crystallinity of a constrained structure and the alteration of the compatibility between the thin and thick filaments driven by ionic interactions. ATP hydrolysis boosts the relaxation process. A strong protein scaffold, engineered during the evolutionary process and based on the selective anchoring of coordinated filaments, directs a demixing tendency of the two filaments toward a sliding motion along the fiber axis. The Huxley-Hanson sliding filament hypothesis aimed to explain the contraction-relaxation function of the striated muscle, but does not offer any clue on the overall assembling mechanism of the myofibril.
Full Text
Duke Authors
Cited Authors
- Ciferri, A; Crumbliss, AL
Published Date
- January 2018
Published In
Volume / Issue
- 6 /
Start / End Page
- 570 -
PubMed ID
- 30555818
Pubmed Central ID
- 30555818
Electronic International Standard Serial Number (EISSN)
- 2296-2646
International Standard Serial Number (ISSN)
- 2296-2646
Digital Object Identifier (DOI)
- 10.3389/fchem.2018.00570
Language
- eng