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Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis.

Publication ,  Journal Article
Kabbara, SW; Zangwill, LM; Mundae, R; Hammel, N; Bowd, C; Medeiros, FA; Weinreb, RN; Belghith, A
Published in: Br J Ophthalmol
March 2018

AIM: To compare the cube and radial scan patterns of the spectral domain optical coherence tomography (SD-OCT) for quantifying the Bruch's membrane opening minimum rim width (BMO-MRW). METHODS: Sixty healthy eyes and 189 glaucomatous eyes were included. The optic nerve head cube and radial pattern scans were acquired using Spectralis SD-OCT. BMO-MRWs were automatically delineated using the San Diego Automated Layer Segmentation Algorithm. The BMO-MRW diagnostic accuracy for glaucoma detection and rates of change derived from the two scan patterns were compared. RESULTS: There was a significant difference between the baseline global BMO-MRW measurements of cube and radial scans for healthy (301.9±57.8 µm and 334.7±61.8 µm, respectively, p<0.003) and glaucoma eyes (181.2±63.0 µm and 210.2±67.2 µm, respectively, p<0.001). The area under the receiver operating characteristic curve for differentiating between healthy and glaucoma eyes was 0.90 for both the radial scan-based and cube scan-based BMO-MRW. No significant difference in the rate of BMO-MRW change (mean follow-up years) by scan pattern was found among both healthy (cube: -1.47 µm/year, radial: -1.53 µm/year; p=0.48) (1.6 years) and glaucoma eyes (cube: -2.37 µm/year, radial: -2.28 µm/year; p=0.45) (2.6 years). CONCLUSION: Although the cube scan-based BMO-MRW was significantly smaller than the radial scan-based BMO-MRW, we found no significant difference between the two scan patterns for detecting glaucoma, identifying BMO location and measuring the rate of BMO-MRW change. These results suggest that although BMO-MRW estimates are not interchangeable, both scan patterns can be used for monitoring BMO-MRW changes over time.

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Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

March 2018

Volume

102

Issue

3

Start / End Page

344 / 351

Location

England

Related Subject Headings

  • Young Adult
  • Visual Fields
  • Tomography, Optical Coherence
  • Retinal Ganglion Cells
  • Reproducibility of Results
  • ROC Curve
  • Optic Disk
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Nerve Fibers
 

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Kabbara, S. W., Zangwill, L. M., Mundae, R., Hammel, N., Bowd, C., Medeiros, F. A., … Belghith, A. (2018). Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis. Br J Ophthalmol, 102(3), 344–351. https://doi.org/10.1136/bjophthalmol-2016-310111
Kabbara, Sami W., Linda M. Zangwill, Rusdeep Mundae, Naama Hammel, Christopher Bowd, Felipe A. Medeiros, Robert N. Weinreb, and Akram Belghith. “Comparing optical coherence tomography radial and cube scan patterns for measuring Bruch's membrane opening minimum rim width (BMO-MRW) in glaucoma and healthy eyes: cross-sectional and longitudinal analysis.Br J Ophthalmol 102, no. 3 (March 2018): 344–51. https://doi.org/10.1136/bjophthalmol-2016-310111.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

March 2018

Volume

102

Issue

3

Start / End Page

344 / 351

Location

England

Related Subject Headings

  • Young Adult
  • Visual Fields
  • Tomography, Optical Coherence
  • Retinal Ganglion Cells
  • Reproducibility of Results
  • ROC Curve
  • Optic Disk
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Nerve Fibers