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The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.

Publication ,  Journal Article
Zangwill, LM; Ayyagari, R; Liebmann, JM; Girkin, CA; Feldman, R; Dubiner, H; Dirkes, KA; Holmann, M; Williams-Steppe, E; Hammel, N; Vega, S ...
Published in: Ophthalmology
January 2019

PURPOSE: To describe the study protocol and baseline characteristics of the African Descent and Glaucoma Evaluation Study (ADAGES) III. DESIGN: Cross-sectional, case-control study. PARTICIPANTS: Three thousand two hundred sixty-six glaucoma patients and control participants without glaucoma of African or European descent were recruited from 5 study centers in different regions of the United States. METHODS: Individuals of African descent (AD) and European descent (ED) with primary open-angle glaucoma (POAG) and control participants completed a detailed demographic and medical history interview. Standardized height, weight, and blood pressure measurements were obtained. Saliva and blood samples to provide serum, plasma, DNA, and RNA were collected for standardized processing. Visual fields, stereoscopic disc photographs, and details of the ophthalmic examination were obtained and transferred to the University of California, San Diego, Data Coordinating Center for standardized processing and quality review. MAIN OUTCOME MEASURES: Participant gender, age, race, body mass index, blood pressure, history of smoking and alcohol use in POAG patients and control participants were described. Ophthalmic measures included intraocular pressure, visual field mean deviation, central corneal thickness, glaucoma medication use, or past glaucoma surgery. Ocular conditions, including diabetic retinopathy, age-related macular degeneration, and past cataract surgery, were recorded. RESULTS: The 3266 ADAGES III study participants in this report include 2146 AD POAG patients, 695 ED POAG patients, 198 AD control participants, and 227 ED control participants. The AD POAG patients and control participants were significantly younger (both, 67.4 years) than ED POAG patients and control participants (73.4 and 70.2 years, respectively). After adjusting for age, AD POAG patients had different phenotypic characteristics compared with ED POAG patients, including higher intraocular pressure, worse visual acuity and visual field mean deviation, and thinner corneas (all P < 0.001). Family history of glaucoma did not differ between AD and ED POAG patients. CONCLUSIONS: With its large sample size, extensive specimen collection, and deep phenotyping of AD and ED glaucoma patients and control participants from different regions in the United States, the ADAGES III genomics study will address gaps in our knowledge of the genetics of POAG in this high-risk population.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2019

Volume

126

Issue

1

Start / End Page

156 / 170

Location

United States

Related Subject Headings

  • White People
  • Visual Fields
  • Visual Acuity
  • Research Design
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure
 

Citation

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Zangwill, L. M., Ayyagari, R., Liebmann, J. M., Girkin, C. A., Feldman, R., Dubiner, H., … African Descent and Glaucoma Evaluation Study III Genomics Study Group, . (2019). The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data. Ophthalmology, 126(1), 156–170. https://doi.org/10.1016/j.ophtha.2017.11.031
Zangwill, Linda M., Radha Ayyagari, Jeffrey M. Liebmann, Christopher A. Girkin, Robert Feldman, Harvey Dubiner, Keri A. Dirkes, et al. “The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.Ophthalmology 126, no. 1 (January 2019): 156–70. https://doi.org/10.1016/j.ophtha.2017.11.031.
Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, et al. The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data. Ophthalmology. 2019 Jan;126(1):156–70.
Zangwill, Linda M., et al. “The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data.Ophthalmology, vol. 126, no. 1, Jan. 2019, pp. 156–70. Pubmed, doi:10.1016/j.ophtha.2017.11.031.
Zangwill LM, Ayyagari R, Liebmann JM, Girkin CA, Feldman R, Dubiner H, Dirkes KA, Holmann M, Williams-Steppe E, Hammel N, Saunders LJ, Vega S, Sandow K, Roll K, Slight R, Auerbach D, Samuels BC, Panarelli JF, Mitchell JP, Al-Aswad LA, Park SC, Tello C, Cotliar J, Bansal R, Sidoti PA, Cioffi GA, Blumberg D, Ritch R, Bell NP, Blieden LS, Davis G, Medeiros FA, Ng MCY, Das SK, Palmer ND, Divers J, Langefeld CD, Freedman BI, Bowden DW, Christopher MA, Chen Y-DI, Guo X, Taylor KD, Rotter JI, Weinreb RN, African Descent and Glaucoma Evaluation Study III Genomics Study Group. The African Descent and Glaucoma Evaluation Study (ADAGES) III: Contribution of Genotype to Glaucoma Phenotype in African Americans: Study Design and Baseline Data. Ophthalmology. 2019 Jan;126(1):156–170.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

January 2019

Volume

126

Issue

1

Start / End Page

156 / 170

Location

United States

Related Subject Headings

  • White People
  • Visual Fields
  • Visual Acuity
  • Research Design
  • Polymorphism, Single Nucleotide
  • Phenotype
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Intraocular Pressure