Association between corneal biomechanical properties and glaucoma severity


Journal Article

• Purpose: To investigate the association between corneal biomechanical parameters using the Ocular Response Analyzer (ORA) and glaucoma severity. • Design: Observational cross-sectional study. • Methods: Two hundred ninety-nine eyes of 191 patients with confirmed or suspect glaucoma were recruited at the University of California, San Diego. Corneal hysteresis (CH) and corneal resistance factor (CRF) were obtained from all participants. Standard automated perimetry was done using the 24-2 Swedish Interactive Threshold Algorithm. Retinal nerve fiber layer (RNFL) thickness measurements were obtained using GDx ECC and spectral-domain optical coherence tomography (SD-OCT). The association between ORA parameters and disease severity was evaluated using univariable and multivariable regression models. • Results: CH and CRF were both positively associated with mean defect (MD) (R2 = 0.03; P <.01 and R2 = 0.10; P <.01, respectively). In multivariable analysis, the association between CRF and MD remained significant while CH to MD did not (P <.01 and P =.77). In the GDx ECC subgroup (204 eyes), there was a weak association between CH and CRF and average RNFL thickness (R2 = 0.07; P <.01 and R2 = 0.05; P <.01, respectively), which was not observed in the SD-OCT subgroup (146 eyes) (R 2 = 0.01; P =.30 and R2 = 0.01; P =.21). After adjusting for central corneal thickness, age, and axial length, the relationship of CH and CRF to RNFL thickness no longer reached statistical significance. • Conclusions: The current study found only a weak relationship between corneal biomechanical parameters and measures of structural and functional damage in glaucoma. © 2012 Elsevier Inc. All rights reserved.

Full Text

Duke Authors

Cited Authors

  • Mansouri, K; Leite, MT; Weinreb, RN; Tafreshi, A; Zangwill, LM; Medeiros, FA

Published Date

  • January 1, 2012

Published In

Volume / Issue

  • 153 / 3

Start / End Page

  • 419 - 427.e1

Electronic International Standard Serial Number (EISSN)

  • 1879-1891

International Standard Serial Number (ISSN)

  • 0002-9394

Digital Object Identifier (DOI)

  • 10.1016/j.ajo.2011.08.022

Citation Source

  • Scopus