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Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve.

Publication ,  Journal Article
Monteiro, MLR; Moura, FC; Medeiros, FA
Published in: Am J Ophthalmol
April 2008

PURPOSE: To compare the abilities of scanning laser polarimetry (SLP) with enhanced corneal compensation (ECC) and variable corneal compensation (VCC) modes for detection of retinal nerve fiber layer (RNFL) loss in eyes with band atrophy (BA) of the optic nerve. DESIGN: Cross-sectional study. METHODS: Thirty-seven eyes from 37 patients with BA and temporal visual field defect from chiasmal compression and 40 eyes from 40 healthy subjects were studied. Subjects underwent standard automated perimetry and RNFL measurements using an SLP device equipped with VCC and ECC. Receiver operating characteristic (ROC) curves were calculated for each parameter. Pearson correlation coefficients were obtained to evaluate the relationship between RNFL thickness parameters and severity of visual field loss, as assessed by the temporal mean defect. RESULTS: All RNFL thickness parameters were significantly lower in eyes with BA compared with normal eyes with both compensation modes. However, no statistically significant differences were observed in the areas under the ROC curves for the different parameters between GDx VCC and ECC (Carl Zeiss Meditec, Inc, Dublin, California, USA). Structure-function relationships also were similar for both compensation modes. CONCLUSIONS: No significant differences were found between the diagnostic accuracy of GDx ECC and that of VCC for detection of BA of the optic nerve. The use of GDx ECC does not seem to provide a better evaluation of RNFL loss on the temporal and nasal sectors of the peripapillary retina in subjects with BA of the optic nerve.

Duke Scholars

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

April 2008

Volume

145

Issue

4

Start / End Page

747 / 754

Location

United States

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Retinal Ganglion Cells
  • Reproducibility of Results
  • ROC Curve
  • Prospective Studies
  • Pituitary Neoplasms
  • Optic Atrophy
  • Ophthalmoscopy
  • Ophthalmology & Optometry
 

Citation

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Monteiro, M. L. R., Moura, F. C., & Medeiros, F. A. (2008). Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve. Am J Ophthalmol, 145(4), 747–754. https://doi.org/10.1016/j.ajo.2007.11.023
Monteiro, Mário L. R., Frederico C. Moura, and Felipe A. Medeiros. “Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve.Am J Ophthalmol 145, no. 4 (April 2008): 747–54. https://doi.org/10.1016/j.ajo.2007.11.023.
Monteiro, Mário L. R., et al. “Scanning laser polarimetry with enhanced corneal compensation for detection of axonal loss in band atrophy of the optic nerve.Am J Ophthalmol, vol. 145, no. 4, Apr. 2008, pp. 747–54. Pubmed, doi:10.1016/j.ajo.2007.11.023.
Journal cover image

Published In

Am J Ophthalmol

DOI

ISSN

0002-9394

Publication Date

April 2008

Volume

145

Issue

4

Start / End Page

747 / 754

Location

United States

Related Subject Headings

  • Visual Fields
  • Vision Disorders
  • Retinal Ganglion Cells
  • Reproducibility of Results
  • ROC Curve
  • Prospective Studies
  • Pituitary Neoplasms
  • Optic Atrophy
  • Ophthalmoscopy
  • Ophthalmology & Optometry