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Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness.

Publication ,  Journal Article
Vizzeri, G; Weinreb, RN; Gonzalez-Garcia, AO; Bowd, C; Medeiros, FA; Sample, PA; Zangwill, LM
Published in: Br J Ophthalmol
June 2009

BACKGROUND/AIMS: To evaluate spectral-domain (SD) optical coherence tomography (OCT) reproducibility and assess the agreement between SD-OCT and Time-Domain (TD) OCT retinal nerve fibre layer (RNFL) measurements. METHODS: Three Cirrus-SD-OCT scans and one Stratus-TD-OCT scan were obtained from Diagnostic Innovations in Glaucoma Study (DIGS) healthy participants and glaucoma patients on the same day. Repeatability was evaluated using Sw (within-subject standard deviation), CV (coefficient of variation) and ICC (intraclass correlation coefficient). Agreement was assessed using correlation and Bland-Altman plots. RESULTS: 16 healthy participants (32 eyes) and 39 patients (78 eyes) were included. SD-OCT reproducibility was excellent in both groups. The CV and ICC for Average RNFL thickness were 1.5% and 0.96, respectively, in healthy eyes and 1.6% and 0.98, respectively, in patient eyes. Correlations between RNFL parameters were strong, particularly for average RNFL thickness (R(2) = 0.92 in patient eyes). Bland-Altman plots showed good agreement between instruments, with better agreement for average RNFL thickness than for sectoral RNFL parameters (for example, at 90 microm average RNFL thickness, 95% limits of agreement were -13.1 to 0.9 for healthy eyes and -16.2 to -0.3 microm for patient eyes). CONCLUSIONS: SD-OCT measurements were highly repeatable in healthy and patient eyes. Although the agreement between instruments was good, TD-OCT provided thicker RNFL measurements than SD-OCT. Measurements with these instruments should not be considered interchangeable.

Duke Scholars

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

June 2009

Volume

93

Issue

6

Start / End Page

775 / 781

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Neurons
  • Reproducibility of Results
  • Prospective Studies
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male
  • Humans
  • Glaucoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Vizzeri, G., Weinreb, R. N., Gonzalez-Garcia, A. O., Bowd, C., Medeiros, F. A., Sample, P. A., & Zangwill, L. M. (2009). Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness. Br J Ophthalmol, 93(6), 775–781. https://doi.org/10.1136/bjo.2008.150698
Vizzeri, G., R. N. Weinreb, A. O. Gonzalez-Garcia, C. Bowd, F. A. Medeiros, P. A. Sample, and L. M. Zangwill. “Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness.Br J Ophthalmol 93, no. 6 (June 2009): 775–81. https://doi.org/10.1136/bjo.2008.150698.
Vizzeri G, Weinreb RN, Gonzalez-Garcia AO, Bowd C, Medeiros FA, Sample PA, et al. Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness. Br J Ophthalmol. 2009 Jun;93(6):775–81.
Vizzeri, G., et al. “Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness.Br J Ophthalmol, vol. 93, no. 6, June 2009, pp. 775–81. Pubmed, doi:10.1136/bjo.2008.150698.
Vizzeri G, Weinreb RN, Gonzalez-Garcia AO, Bowd C, Medeiros FA, Sample PA, Zangwill LM. Agreement between spectral-domain and time-domain OCT for measuring RNFL thickness. Br J Ophthalmol. 2009 Jun;93(6):775–781.

Published In

Br J Ophthalmol

DOI

EISSN

1468-2079

Publication Date

June 2009

Volume

93

Issue

6

Start / End Page

775 / 781

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Retinal Neurons
  • Reproducibility of Results
  • Prospective Studies
  • Ophthalmology & Optometry
  • Nerve Fibers
  • Middle Aged
  • Male
  • Humans
  • Glaucoma