Evaluation of the influence of corneal biomechanical properties on intraocular pressure measurements using the ocular response analyzer.

Journal Article (Journal Article)

PURPOSE: The Ocular Response Analyzer (ORA) proposes to measure corneal biomechanical properties in vivo by monitoring and analyzing the corneal behavior when this structure is submitted to a force induced by an air jet. The purpose of this study was to evaluate the relationship between corneal biomechanical properties and corneal-compensated intraocular pressure (IOPCC) measurements as obtained by the ORA and Goldmann applanation tonometry (GAT) measurements. DESIGN: Observational clinical study. METHODS: The study included 153 eyes of 78 subjects. All subjects underwent IOP evaluation with the ORA and GAT, and also measurements of central corneal thickness (CCT), corneal curvature, and axial length. Univariable and multivariable regression analysis were used to evaluate the associations between IOP (as measured with GAT and ORA) and CCT, corneal curvature, axial length, and age. Bland and Altman plots were used to evaluate the agreement between IOP measurements obtained by GAT and ORA. RESULTS: GAT IOP measurements were significantly associated with CCT (P=0.001) and corneal curvature (P<0.001), whereas ORA IOPCC measurements were not associated with any of the ocular variables. The difference between GAT and IOPCC measurements was significantly influenced by corneal thickness. Patients with thicker corneas tended to have higher GAT IOP measurements compared with IOPCC, whereas in patients with thin corneas, GAT IOP measurements tended to be lower than IOPCC. CONCLUSIONS: ORA IOPCC measurements seem to provide an estimate of IOP that is less influenced by corneal properties than those provided by GAT.

Full Text

Duke Authors

Cited Authors

  • Medeiros, FA; Weinreb, RN

Published Date

  • October 2006

Published In

Volume / Issue

  • 15 / 5

Start / End Page

  • 364 - 370

PubMed ID

  • 16988597

International Standard Serial Number (ISSN)

  • 1057-0829

Digital Object Identifier (DOI)

  • 10.1097/01.ijg.0000212268.42606.97


  • eng

Conference Location

  • United States