Resistance of cats to the diabetogenic effect of alloxan.

Journal Article (Journal Article)

Experimental diabetes mellitus can be induced chemically in many species of animals with streptozotocin or alloxan. However, the cat is known to be resistant to the diabetogenic effect of streptozotocin. The purpose of this study was to find the optimal dose and rate of injection of alloxan to consistently produce hyperglycemia (blood sugar levels greater than 300 mg/dl) in cats. Alloxan was administered to 22 cats at various concentrations (50, 100 and 150 mg/kg) and different rates of injection (0.5, 1.0 and 1.5 ml/min). No hyperglycemic effect was observed at any of the concentrations or different rates of injection. Cats receiving high concentrations and/or high rates of injection of alloxan died due to kidney damage. The results of this study suggest that the cat is resistant to the diabetogenic effect of alloxan, but is susceptible to its toxic side effects.

Full Text

Duke Authors

Cited Authors

  • Hatchell, DL; Reiser, HJ; Bresnahan, JF; Whitworth, UG

Published Date

  • February 1, 1986

Published In

Volume / Issue

  • 36 / 1

Start / End Page

  • 37 - 40

PubMed ID

  • 3959532

International Standard Serial Number (ISSN)

  • 0023-6764


  • eng

Conference Location

  • United States