Treatment of xerophthalmia with retinol, tretinoin, and etretinate.

Journal Article (Journal Article)

Topical retinol, tretinoin (all-trans-retinoic acid) and etretinate (a synthetic retinoid) were used in rabbits to treat experimental xerophthalmia due to vitamin A deficiency. Both 0.2% retinol and 0.1% and 0.2% tretinoin effectively reversed abnormal corneal epithelial keratinization within one to two days and restored corneal clarity within two to four days following topical application three times per day. Etretinate was ineffective in the concentration used (0.2%). In addition, application of tretinoin to one eye effectively reversed xerophthalmic changes in the other eye. Retinol did not have an effect on the other eye.

Full Text

Duke Authors

Cited Authors

  • Hatchell, DL; Faculjak, M; Kubicek, D

Published Date

  • June 1984

Published In

Volume / Issue

  • 102 / 6

Start / End Page

  • 926 - 927

PubMed ID

  • 6732578

International Standard Serial Number (ISSN)

  • 0003-9950

Digital Object Identifier (DOI)

  • 10.1001/archopht.1984.01040030746036


  • eng

Conference Location

  • United States