Treatment of xerophthalmia with retinol, tretinoin, and etretinate.
Journal Article (Journal Article)
Topical retinol, tretinoin (all-trans-retinoic acid) and etretinate (a synthetic retinoid) were used in rabbits to treat experimental xerophthalmia due to vitamin A deficiency. Both 0.2% retinol and 0.1% and 0.2% tretinoin effectively reversed abnormal corneal epithelial keratinization within one to two days and restored corneal clarity within two to four days following topical application three times per day. Etretinate was ineffective in the concentration used (0.2%). In addition, application of tretinoin to one eye effectively reversed xerophthalmic changes in the other eye. Retinol did not have an effect on the other eye.
Full Text
Duke Authors
Cited Authors
- Hatchell, DL; Faculjak, M; Kubicek, D
Published Date
- June 1984
Published In
Volume / Issue
- 102 / 6
Start / End Page
- 926 - 927
PubMed ID
- 6732578
International Standard Serial Number (ISSN)
- 0003-9950
Digital Object Identifier (DOI)
- 10.1001/archopht.1984.01040030746036
Language
- eng
Conference Location
- United States