Antithrombotic effect of ticlopidine in an experimental model of retinal vein occlusion.

Published

Journal Article

PURPOSE: Ticlopidine inhibits adenosine diphosphate (ADP)-induced platelet aggregation and may be effective in patients with retinal vein occlusions (RVO). This study tests the efficacy of ticlopidine in an animal model of RVO. METHODS: Rose bengal-mediated argon laser photothrombosis of retinal veins was created in rabbits pretreated with oral ticlopidine, aspirin, or saline. The number of laser spots necessary to produce a partial or complete RVO was recorded and tabulated. RESULTS: Pretreatment with ticlopidine significantly increased the number of laser spots needed to produce a partial (P =.02), or a complete (P =.002) RVO as compared to the control group. Pretreatment with ticlopidine significantly increased the number of laser spots needed to produce a partial RVO (P =.02). Pretreatment with aspirin significantly increased the number of laser spots needed to produce a complete RVO (P =.002). CONCLUSION: Ticlopidine may be a useful antiplatelet agent for the treatment of patients with RVO. Patients treated with ticlopidine should be monitored for the possible development of hematologic disorders.

Full Text

Duke Authors

Cited Authors

  • Arroyo, JG; Dastgheib, K; Hatchell, DL

Published Date

  • July 2001

Published In

Volume / Issue

  • 45 / 4

Start / End Page

  • 359 - 362

PubMed ID

  • 11485766

Pubmed Central ID

  • 11485766

International Standard Serial Number (ISSN)

  • 0021-5155

Language

  • eng

Conference Location

  • Japan