Skip to main content
Journal cover image

Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo

Publication ,  Journal Article
Novack, RL; Stefánsson, E; Hatchell, DL
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology
January 1, 1990

The effects of acute intraocular pressure (IOP) on the reduction/oxidation ratio of cytochrome a, a 3 were measured from intact cat optic nerve by microfiber reflection spectrophotometry. This enabled the real-time analysis of optic nerve-head oxidative metabolism following IOP or mean arterial pressure (MAP) changes. Findings included: (1) cytochrome a, a 3 became more reduced and relative blood volume decreased at lower perfusion pressures, even at IOP of <20 mm Hg; (2) metabolic inhibition began at variable perfusion pressures but invariably progressed as perfusion pressure declined; and (3) increased IOP or decreased MAP caused metabolic inhibition. These findings demonstrate that: (1) optic nerve metabolic dysfunction is possible at low IOPs; (2) lowering IOP can reverse metabolic dysfunction; (3) the metabolic response is dependent on IOP and/or MAP changes; and (4) the metabolic inhibition is related to optic nerve ischemia. © 1990 Springer-Verlag.

Duke Scholars

Published In

Graefe's Archive for Clinical and Experimental Ophthalmology

DOI

EISSN

1435-702X

ISSN

0721-832X

Publication Date

January 1, 1990

Volume

228

Issue

1

Start / End Page

128 / 133

Related Subject Headings

  • Ophthalmology & Optometry
  • 1113 Opthalmology and Optometry
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Novack, R. L., Stefánsson, E., & Hatchell, D. L. (1990). Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo. Graefe’s Archive for Clinical and Experimental Ophthalmology, 228(1), 128–133. https://doi.org/10.1007/BF02764306
Novack, R. L., E. Stefánsson, and D. L. Hatchell. “Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo.” Graefe’s Archive for Clinical and Experimental Ophthalmology 228, no. 1 (January 1, 1990): 128–33. https://doi.org/10.1007/BF02764306.
Novack RL, Stefánsson E, Hatchell DL. Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo. Graefe’s Archive for Clinical and Experimental Ophthalmology. 1990 Jan 1;228(1):128–33.
Novack, R. L., et al. “Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo.” Graefe’s Archive for Clinical and Experimental Ophthalmology, vol. 228, no. 1, Jan. 1990, pp. 128–33. Scopus, doi:10.1007/BF02764306.
Novack RL, Stefánsson E, Hatchell DL. Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo. Graefe’s Archive for Clinical and Experimental Ophthalmology. 1990 Jan 1;228(1):128–133.
Journal cover image

Published In

Graefe's Archive for Clinical and Experimental Ophthalmology

DOI

EISSN

1435-702X

ISSN

0721-832X

Publication Date

January 1, 1990

Volume

228

Issue

1

Start / End Page

128 / 133

Related Subject Headings

  • Ophthalmology & Optometry
  • 1113 Opthalmology and Optometry