Intraocular pressure effects on optic nerve-head oxidative metabolism measured in vivo

Journal Article

The effects of acute intraocular pressure (IOP) on the reduction/oxidation ratio of cytochrome a, a 3 were measured from intact cat optic nerve by microfiber reflection spectrophotometry. This enabled the real-time analysis of optic nerve-head oxidative metabolism following IOP or mean arterial pressure (MAP) changes. Findings included: (1) cytochrome a, a 3 became more reduced and relative blood volume decreased at lower perfusion pressures, even at IOP of <20 mm Hg; (2) metabolic inhibition began at variable perfusion pressures but invariably progressed as perfusion pressure declined; and (3) increased IOP or decreased MAP caused metabolic inhibition. These findings demonstrate that: (1) optic nerve metabolic dysfunction is possible at low IOPs; (2) lowering IOP can reverse metabolic dysfunction; (3) the metabolic response is dependent on IOP and/or MAP changes; and (4) the metabolic inhibition is related to optic nerve ischemia. © 1990 Springer-Verlag.

Full Text

Duke Authors

Cited Authors

  • Novack, RL; Stefánsson, E; Hatchell, DL

Published Date

  • January 1, 1990

Published In

Volume / Issue

  • 228 / 1

Start / End Page

  • 128 - 133

Electronic International Standard Serial Number (EISSN)

  • 1435-702X

International Standard Serial Number (ISSN)

  • 0721-832X

Digital Object Identifier (DOI)

  • 10.1007/BF02764306

Citation Source

  • Scopus