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Effective effectors: How T cells access and infiltrate the central nervous system.

Publication ,  Journal Article
Congdon, KL; Sanchez-Perez, LA; Sampson, JH
Published in: Pharmacol Ther
May 2019

Several Phase II and III clinical trials have demonstrated that immunotherapy can induce objective responses in otherwise refractory malignancies in tumors outside the central nervous system. In large part, effector T cells mediate much of the antitumor efficacy in these trials, and potent antitumor T cells can be generated through vaccination, immune checkpoint blockade, adoptive transfer, and genetic manipulation. However, activated T cells must still traffic to, infiltrate, and persist within tumor in order to mediate tumor lysis. These requirements for efficacy pose unique challenges for brain tumor immunotherapy, due to specific anatomical barriers and populations of specialized immune cells within the central nervous system that function to constrain immunity. Both autoimmune and infectious diseases of the central nervous system provide a wealth of information on how T cells can successfully migrate to the central nervous system and then engender sustained immune responses. In this review, we will examine the commonalities in the efferent arm of immunity to the brain for autoimmunity, infection, and tumor immunotherapy to identify key factors underlying potent immune responses.

Duke Scholars

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Published In

Pharmacol Ther

DOI

EISSN

1879-016X

Publication Date

May 2019

Volume

197

Start / End Page

52 / 60

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Pharmacology & Pharmacy
  • Humans
  • Central Nervous System
  • Antigen Presentation
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences
 

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Congdon, K. L., Sanchez-Perez, L. A., & Sampson, J. H. (2019). Effective effectors: How T cells access and infiltrate the central nervous system. Pharmacol Ther, 197, 52–60. https://doi.org/10.1016/j.pharmthera.2018.12.007
Congdon, Kendra L., Luis A. Sanchez-Perez, and John H. Sampson. “Effective effectors: How T cells access and infiltrate the central nervous system.Pharmacol Ther 197 (May 2019): 52–60. https://doi.org/10.1016/j.pharmthera.2018.12.007.
Congdon KL, Sanchez-Perez LA, Sampson JH. Effective effectors: How T cells access and infiltrate the central nervous system. Pharmacol Ther. 2019 May;197:52–60.
Congdon, Kendra L., et al. “Effective effectors: How T cells access and infiltrate the central nervous system.Pharmacol Ther, vol. 197, May 2019, pp. 52–60. Pubmed, doi:10.1016/j.pharmthera.2018.12.007.
Congdon KL, Sanchez-Perez LA, Sampson JH. Effective effectors: How T cells access and infiltrate the central nervous system. Pharmacol Ther. 2019 May;197:52–60.
Journal cover image

Published In

Pharmacol Ther

DOI

EISSN

1879-016X

Publication Date

May 2019

Volume

197

Start / End Page

52 / 60

Location

England

Related Subject Headings

  • T-Lymphocytes
  • Pharmacology & Pharmacy
  • Humans
  • Central Nervous System
  • Antigen Presentation
  • Animals
  • 3214 Pharmacology and pharmaceutical sciences
  • 1115 Pharmacology and Pharmaceutical Sciences