Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer's disease.

Published

Journal Article

INTRODUCTION: Primary age-related tauopathy (PART) is a recently described entity that can cause cognitive impairment in the absence of Alzheimer's disease (AD). Here, we compared neuropathological features, tau haplotypes, apolipoprotein E (APOE) genotypes, and cognitive profiles in age-matched subjects with PART and AD pathology. METHODS: Brain autopsies (n = 183) were conducted on participants 85 years and older from the Baltimore Longitudinal Study of Aging and Johns Hopkins Alzheimer's Disease Research Center. Participants, normal at enrollment, were followed with periodic cognitive evaluations until death. RESULTS: Compared with AD, PART subjects showed significantly slower rates of decline on measures of memory, language, and visuospatial performance. They also showed lower APOE ε4 allele frequency (4.1% vs. 17.6%, P = .0046). DISCUSSION: Our observations suggest that PART is separate from AD and its distinction will be important for the clinical management of patients with cognitive impairment and for public health care planning.

Full Text

Duke Authors

Cited Authors

  • Bell, WR; An, Y; Kageyama, Y; English, C; Rudow, GL; Pletnikova, O; Thambisetty, M; O'Brien, R; Moghekar, AR; Albert, MS; Rabins, PV; Resnick, SM; Troncoso, JC

Published Date

  • January 2019

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 8 - 16

PubMed ID

  • 30465754

Pubmed Central ID

  • 30465754

Electronic International Standard Serial Number (EISSN)

  • 1552-5279

Digital Object Identifier (DOI)

  • 10.1016/j.jalz.2018.07.215

Language

  • eng

Conference Location

  • United States